Clinical commentary: Granulocytic fragments in sepsis

R. R. Dalton, J. S. Krauss, Dorth Greer Falls, G. K. Fuller

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Granulocytic fragments have been described in the peripheral blood of patients with sepsis and the systemic inflammatory response syndrome (SIRS). Although initially proposed as a morphologic clue for distinguishing the leukoerythroblastosis of sepsis from that of myelophthisis or marrow replacement by tumor, granulocyte-derived fragments may be part of a spectrum of cellular fragmentation associated with pathological inflammation and thrombosis, and thus play an important role in the pathophysiology of sepsis and SIRS. Pathologists, hematologists, and medical technologists should be aware of their existence, the morphologic features that distinguish them from macrothombocytes and schistocytes, and their potential significance.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalAnnals of Clinical and Laboratory Science
Volume31
Issue number4
StatePublished - Nov 1 2001

Fingerprint

Tumors
Systemic Inflammatory Response Syndrome
Sepsis
Blood
Medical Laboratory Personnel
Granulocytes
Thrombosis
Bone Marrow
Inflammation
Neoplasms
Pathologists

Keywords

  • Granulocyte
  • Microparticle
  • Neutrophil
  • Sepsis
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

Dalton, R. R., Krauss, J. S., Falls, D. G., & Fuller, G. K. (2001). Clinical commentary: Granulocytic fragments in sepsis. Annals of Clinical and Laboratory Science, 31(4), 365-368.

Clinical commentary : Granulocytic fragments in sepsis. / Dalton, R. R.; Krauss, J. S.; Falls, Dorth Greer; Fuller, G. K.

In: Annals of Clinical and Laboratory Science, Vol. 31, No. 4, 01.11.2001, p. 365-368.

Research output: Contribution to journalReview article

Dalton, RR, Krauss, JS, Falls, DG & Fuller, GK 2001, 'Clinical commentary: Granulocytic fragments in sepsis', Annals of Clinical and Laboratory Science, vol. 31, no. 4, pp. 365-368.
Dalton, R. R. ; Krauss, J. S. ; Falls, Dorth Greer ; Fuller, G. K. / Clinical commentary : Granulocytic fragments in sepsis. In: Annals of Clinical and Laboratory Science. 2001 ; Vol. 31, No. 4. pp. 365-368.
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