Clinical relevance of benign endometrial cells in postmenopausal women

Raheela Ashfaq, Suash Sharma, Tara Dulley, M. Hossein Saboorian, Momin T. Siddiqui, Claudia Warner

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Our objective was to determine if the finding of benign endometrial cells on a Papanicolaou (Pap) smear of a postmenopausal woman is associated with endometrial/uterine pathology, independent of symptomatology and hormone replacement therapy (HRT) status. The medical records of 146 postmenopausal patients who had a Pap smear showing normal-appearing endometrial cells between January 9, 1997 and January 12, 2000 were reviewed. Uterine pathology for each patient was determined by reviewing the results of endometrial sampling (endometrial biopsy or dilatation and curettage), hysterectomy, or pelvic sonogram, which were performed within 24 mo of the cytologic smear. The results were then correlated with clinical symptomatology and HRT status of each patient at the time the cytologic smear was obtained. Of the 146 Pap smears coded with "endometrial cells in a postmenopausal woman," 50 were excluded due to prior hysterectomy, perimenopausal status, and absence of further follow-up. Of the remaining 96 women, 27 (28%) had benign pathologic findings including polyps, leiomyomata, and simple hyperplasia without atypia, whereas 11 (12%) had significant pathologic findings including hyperplasia with atypia, adenocarcinoma, mixed Mullerian tumor, and leiomyosarcoma. Of the 11 patients with significant pathology, only one patient did not have abnormal vaginal bleeding but instead had a 30-wk-size irregular uterus on examination, and only 2 patients received hormone replacement therapy. In conclusion, Reporting endometrial cells on Pap smears in postmenopausal women did not lead to the diagnosis of any cases of significant pathology that would have gone unsuspected clinically. Moreover, HRT status did not affect the incidence of normal endometrial cells on Pap smears in postmenopausal women, nor did it aid in distinguishing which postmenopausal women had endometrial/uterine pathology. This calls into question the usefulness of the current Bethesda guideline to report "benign endometrial cells in a postmenopausal woman." Diagn. Cytophatol. 2001.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalDiagnostic Cytopathology
Volume25
Issue number4
DOIs
StatePublished - Oct 9 2001

Fingerprint

Papanicolaou Test
Hormone Replacement Therapy
Pathology
Hysterectomy
Hyperplasia
Mullerian Mixed Tumor
Dilatation and Curettage
Leiomyosarcoma
Uterine Hemorrhage
Status Epilepticus
Leiomyoma
Polyps
Uterus
Medical Records
Adenocarcinoma
Guidelines
Biopsy
Incidence

Keywords

  • Benign endometrial cells
  • Bethesda system
  • Endometrial carcinoma
  • Postmenopausal women

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Ashfaq, R., Sharma, S., Dulley, T., Hossein Saboorian, M., Siddiqui, M. T., & Warner, C. (2001). Clinical relevance of benign endometrial cells in postmenopausal women. Diagnostic Cytopathology, 25(4), 235-238. https://doi.org/10.1002/dc.2045

Clinical relevance of benign endometrial cells in postmenopausal women. / Ashfaq, Raheela; Sharma, Suash; Dulley, Tara; Hossein Saboorian, M.; Siddiqui, Momin T.; Warner, Claudia.

In: Diagnostic Cytopathology, Vol. 25, No. 4, 09.10.2001, p. 235-238.

Research output: Contribution to journalArticle

Ashfaq, R, Sharma, S, Dulley, T, Hossein Saboorian, M, Siddiqui, MT & Warner, C 2001, 'Clinical relevance of benign endometrial cells in postmenopausal women', Diagnostic Cytopathology, vol. 25, no. 4, pp. 235-238. https://doi.org/10.1002/dc.2045
Ashfaq R, Sharma S, Dulley T, Hossein Saboorian M, Siddiqui MT, Warner C. Clinical relevance of benign endometrial cells in postmenopausal women. Diagnostic Cytopathology. 2001 Oct 9;25(4):235-238. https://doi.org/10.1002/dc.2045
Ashfaq, Raheela ; Sharma, Suash ; Dulley, Tara ; Hossein Saboorian, M. ; Siddiqui, Momin T. ; Warner, Claudia. / Clinical relevance of benign endometrial cells in postmenopausal women. In: Diagnostic Cytopathology. 2001 ; Vol. 25, No. 4. pp. 235-238.
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