Cognitive impairment and memory loss associated with Histoplasmosis

A case study

Ashlee R. Loughan, Robert Perna, Jeremy Brandon Hertza

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Histoplasmosis is a rare disease caused by inhalation of the fungus Histoplasma capsulatum. It can spread via cerebral circulation to the central nervous system as a manifestation of a disseminated infection; particularly in patients with immune suppression, which can result in isolated ring-enhancing lesions and inflammation in the brain. Of the reported disseminated histoplasmosis cases (approximately 1 in 2000 per year), only 5-20% have evidence of central nervous system involvement. This paper reviews a single case study of a 57-year-old female diagnosed with disseminated CNS histoplasmosis. Patients complaints included reduced short-term memory, word-finding problems, and difficulty organizing, making decisions, getting lost while driving, recalling names, retaining information while reading, and slowed processing speed. There was also a history of mild depression and anxiety. Direct testing revealed deficits in multiple cognitive domains including complex attention, processing speed, semantic fluency, visual scanning, motor speed, set-shifting, naming, nonverbal memory, and verbal memory. Neuropsychological deficits suggest cortical and subcortical brain dysfunction, including anterior, temporal, and mesialoral regions. This case illustrates the need for neuropsychologists to understand histoplasmosis, the related pathophysiology, and the neuropsychological impact; particularly with the potential for delayed progression.

Original languageEnglish (US)
Pages (from-to)514-524
Number of pages11
JournalClinical Neuropsychologist
Volume28
Issue number3
DOIs
StatePublished - Apr 3 2014

Fingerprint

Histoplasmosis
Memory Disorders
Cerebrovascular Circulation
Central Nervous System
Histoplasma
Encephalitis
Temporal Lobe
Rare Diseases
Short-Term Memory
Semantics
Inhalation
Names
Reading
Decision Making
Fungi
Anxiety
Depression
Cognitive Dysfunction
Cognitive Impairment
Brain

Keywords

  • Cognitive
  • Histoplasmosis
  • Neuropsychology

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Cognitive impairment and memory loss associated with Histoplasmosis : A case study. / Loughan, Ashlee R.; Perna, Robert; Hertza, Jeremy Brandon.

In: Clinical Neuropsychologist, Vol. 28, No. 3, 03.04.2014, p. 514-524.

Research output: Contribution to journalArticle

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