Combination antifungal therapy for invasive aspergillosis infection in liver transplant recipients: Report of two patients

Iman E. Bajjoka, Elaine M. Bailey, Jose Antonio Vazquez, Marwan S. Abouljoud

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Invasive aspergillosis in solid organ transplant recipients is associated with mortality of approximately 100%. The search for optimal therapy has led clinicians to administer antifungal combinations. Two orthotopic liver transplant recipients developed invasive aspergillosis (pulmonary and perivertebral) after transplantation and were treated with combination antifungal therapy consisting of liposomal amphotericin B and itraconazole. Although both patients were initially stabilized, they died after 94 and 138 days of antifungal therapy, respectively. Presumably, aspergillosis was the principal cause of death. Antifungal serum concentrations and fungicidal titers in both patients indicated that the drugs may have been antagonistic and thus detrimental.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalPharmacotherapy
Volume19
Issue number1 I
DOIs
StatePublished - Jan 20 1999
Externally publishedYes

Fingerprint

Aspergillosis
Liver
Infection
Invasive Pulmonary Aspergillosis
Itraconazole
Cause of Death
Therapeutics
Transplantation
Transplants
Mortality
Serum
Pharmaceutical Preparations
Transplant Recipients

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Combination antifungal therapy for invasive aspergillosis infection in liver transplant recipients : Report of two patients. / Bajjoka, Iman E.; Bailey, Elaine M.; Vazquez, Jose Antonio; Abouljoud, Marwan S.

In: Pharmacotherapy, Vol. 19, No. 1 I, 20.01.1999, p. 118-123.

Research output: Contribution to journalArticle

@article{3201b46027184e138ec35410c3d899e1,
title = "Combination antifungal therapy for invasive aspergillosis infection in liver transplant recipients: Report of two patients",
abstract = "Invasive aspergillosis in solid organ transplant recipients is associated with mortality of approximately 100{\%}. The search for optimal therapy has led clinicians to administer antifungal combinations. Two orthotopic liver transplant recipients developed invasive aspergillosis (pulmonary and perivertebral) after transplantation and were treated with combination antifungal therapy consisting of liposomal amphotericin B and itraconazole. Although both patients were initially stabilized, they died after 94 and 138 days of antifungal therapy, respectively. Presumably, aspergillosis was the principal cause of death. Antifungal serum concentrations and fungicidal titers in both patients indicated that the drugs may have been antagonistic and thus detrimental.",
author = "Bajjoka, {Iman E.} and Bailey, {Elaine M.} and Vazquez, {Jose Antonio} and Abouljoud, {Marwan S.}",
year = "1999",
month = "1",
day = "20",
doi = "10.1592/phco.19.1.118.30511",
language = "English (US)",
volume = "19",
pages = "118--123",
journal = "Pharmacotherapy",
issn = "0277-0008",
publisher = "Pharmacotherapy Publications Inc.",
number = "1 I",

}

TY - JOUR

T1 - Combination antifungal therapy for invasive aspergillosis infection in liver transplant recipients

T2 - Report of two patients

AU - Bajjoka, Iman E.

AU - Bailey, Elaine M.

AU - Vazquez, Jose Antonio

AU - Abouljoud, Marwan S.

PY - 1999/1/20

Y1 - 1999/1/20

N2 - Invasive aspergillosis in solid organ transplant recipients is associated with mortality of approximately 100%. The search for optimal therapy has led clinicians to administer antifungal combinations. Two orthotopic liver transplant recipients developed invasive aspergillosis (pulmonary and perivertebral) after transplantation and were treated with combination antifungal therapy consisting of liposomal amphotericin B and itraconazole. Although both patients were initially stabilized, they died after 94 and 138 days of antifungal therapy, respectively. Presumably, aspergillosis was the principal cause of death. Antifungal serum concentrations and fungicidal titers in both patients indicated that the drugs may have been antagonistic and thus detrimental.

AB - Invasive aspergillosis in solid organ transplant recipients is associated with mortality of approximately 100%. The search for optimal therapy has led clinicians to administer antifungal combinations. Two orthotopic liver transplant recipients developed invasive aspergillosis (pulmonary and perivertebral) after transplantation and were treated with combination antifungal therapy consisting of liposomal amphotericin B and itraconazole. Although both patients were initially stabilized, they died after 94 and 138 days of antifungal therapy, respectively. Presumably, aspergillosis was the principal cause of death. Antifungal serum concentrations and fungicidal titers in both patients indicated that the drugs may have been antagonistic and thus detrimental.

UR - http://www.scopus.com/inward/record.url?scp=0032918093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032918093&partnerID=8YFLogxK

U2 - 10.1592/phco.19.1.118.30511

DO - 10.1592/phco.19.1.118.30511

M3 - Article

C2 - 9917086

AN - SCOPUS:0032918093

VL - 19

SP - 118

EP - 123

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 1 I

ER -