Comparing Initial Wound Healing and Osteogenesis of Porous Tantalum Trabecular Metal and Titanium Alloy Materials

Sompop Bencharit, Thiago Morelli, Silvana Barros, Jackson T. Seagroves, Steven Kim, Ning Yu, Kevin Byrd, Christian David Brenes Vega, Steven Offenbacher

Research output: Contribution to journalArticle

Abstract

Porous tantalum trabecular metal (PTTM) has long been used in orthopedics to enhance neovascularization, wound healing, and osteogenesis; recently, it has been incorporated into titanium alloy dental implants. However, little is known about the biological responses to PTTM in the human oral cavity. We have hypothesized that, compared with conventional titanium alloy, PTTM has a greater expression of genes specific to neovascularization, wound healing, and osteogenesis during the initial healing period. Twelve subjects requiring at least 4 implants in the mandible were enrolled. Four 3 × 5mm devices, including 2 titanium alloy tapered screws and 2 PTTM cylinders, were placed in the edentulous mandibular areas using a split-mouth design. One device in each group was trephined for analysis at 2 and 4 weeks after placement. RNA microarray analysis and ingenuity pathway analysis were used to analyze osteogenesis gene expression and relevant signaling pathways. Compared to titanium alloy, PTTM samples exhibited significantly higher expressions of genes specific to cell neovascularization, wound healing, and osteogenesis. Several genes-including bone morphogenic proteins, collagens, and growth factors-were upregulated in the PTTM group compared to the titanium alloy control. PTTM materials may enhance the initial healing of dental implants by modifying gene expression profiles.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalThe Journal of oral implantology
Volume45
Issue number3
DOIs
StatePublished - Jun 1 2019

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Tantalum
Titanium
Osteogenesis
Wound Healing
Metals
Dental Implants
Gene Expression
Mouth
Equipment and Supplies
Microarray Analysis
Mandible
Transcriptome
Orthopedics
Intercellular Signaling Peptides and Proteins
Collagen
RNA
Bone and Bones

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Comparing Initial Wound Healing and Osteogenesis of Porous Tantalum Trabecular Metal and Titanium Alloy Materials. / Bencharit, Sompop; Morelli, Thiago; Barros, Silvana; Seagroves, Jackson T.; Kim, Steven; Yu, Ning; Byrd, Kevin; Brenes Vega, Christian David; Offenbacher, Steven.

In: The Journal of oral implantology, Vol. 45, No. 3, 01.06.2019, p. 173-180.

Research output: Contribution to journalArticle

Bencharit, Sompop ; Morelli, Thiago ; Barros, Silvana ; Seagroves, Jackson T. ; Kim, Steven ; Yu, Ning ; Byrd, Kevin ; Brenes Vega, Christian David ; Offenbacher, Steven. / Comparing Initial Wound Healing and Osteogenesis of Porous Tantalum Trabecular Metal and Titanium Alloy Materials. In: The Journal of oral implantology. 2019 ; Vol. 45, No. 3. pp. 173-180.
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