Comparison of central line-associated bloodstream infection rates when changing to a zero fluid displacement intravenous needleless connector in acute care settings

Cynthia C. Chernecky, Denise Macklin, William R. Jarvis, Thomas V. Joshua

Research output: Contribution to journalArticle

8 Scopus citations


This was a multicenter, quasiexperimental, 140-month, acute care study comparing central line-associated bloodstream infection rates associated with positive or negative intravenous connectors to a zero fluid displacement connector. A decrease in central line-associated bloodstream infections was found after changing from either negative or positive intravenous connectors to the zero fluid displacement connector (P =.004) with total cost savings of over $3 million.

Original languageEnglish (US)
Pages (from-to)200-202
Number of pages3
JournalAmerican Journal of Infection Control
Issue number2
StatePublished - Feb 1 2014



  • Comparative effectiveness
  • Mechanical valve
  • Negative pressure
  • Neutral
  • Positive pressure
  • Split septum

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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