Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Ram Kalpatthi, Bruce Thompson, Ming Lu, Winfred C. Wang, Niren Patel, Abdullah Kutlar, Thomas Howard, Lori Luchtman-Jones, Scott T. Miller

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objectives: To investigate the concordance of blood count indices measured locally and at a central laboratory. Design and methods: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated. Results: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally. Conclusion: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalClinical Biochemistry
Volume46
Issue number3
DOIs
Publication statusPublished - Feb 1 2013

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Keywords

  • Clinical trial
  • Complete blood count
  • Neutrophil
  • Shipping
  • Transportation

ASJC Scopus subject areas

  • Clinical Biochemistry

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