Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma

Margaret Frank Guill, M. J. Maloney, R. H. DuRant

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The separate and combined effects of inhaled metaproterenol and atropine sulfate were evaluated in the treatment of 44 episodes of acute asthma occurring in 35 children ranging in age from 13 months to 13 years. Peak expiratory flow rate and pulmonary index were measured before and after each of up to three inhalation treatments. Significant improvement in peak flow rate (P < .04) was noted after the second inhalation of metaproterenol both with and without the combination of atropine sulfate compared with the effects of atropine alone. Patients treated with metaproterenol and metaproterenol combined with atropine also experienced fewer therapeutic failures (2/15 and 2/16, respectively) compared with those treated with atropine (6/13, P < .02). Pulmonary index scores did not differ among the treatment groups. Inhaled metaproterenol appears to be more effective than inhaled atropine sulfate in the treatment of children with acute asthma. The addition of inhaled atropine sulfate appears to offer no advantage over treatment with inhaled metaproterenol alone.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalAnnals of Allergy
Volume59
Issue number5
StatePublished - Dec 1 1987

Fingerprint

Metaproterenol
Atropine
Asthma
Inhalation
Therapeutics
Peak Expiratory Flow Rate
Lung

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma. / Guill, Margaret Frank; Maloney, M. J.; DuRant, R. H.

In: Annals of Allergy, Vol. 59, No. 5, 01.12.1987, p. 367-371.

Research output: Contribution to journalArticle

Guill, Margaret Frank ; Maloney, M. J. ; DuRant, R. H. / Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma. In: Annals of Allergy. 1987 ; Vol. 59, No. 5. pp. 367-371.
@article{ca9ef5ddf3854a41920ac703a5e44965,
title = "Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma",
abstract = "The separate and combined effects of inhaled metaproterenol and atropine sulfate were evaluated in the treatment of 44 episodes of acute asthma occurring in 35 children ranging in age from 13 months to 13 years. Peak expiratory flow rate and pulmonary index were measured before and after each of up to three inhalation treatments. Significant improvement in peak flow rate (P < .04) was noted after the second inhalation of metaproterenol both with and without the combination of atropine sulfate compared with the effects of atropine alone. Patients treated with metaproterenol and metaproterenol combined with atropine also experienced fewer therapeutic failures (2/15 and 2/16, respectively) compared with those treated with atropine (6/13, P < .02). Pulmonary index scores did not differ among the treatment groups. Inhaled metaproterenol appears to be more effective than inhaled atropine sulfate in the treatment of children with acute asthma. The addition of inhaled atropine sulfate appears to offer no advantage over treatment with inhaled metaproterenol alone.",
author = "Guill, {Margaret Frank} and Maloney, {M. J.} and DuRant, {R. H.}",
year = "1987",
month = "12",
day = "1",
language = "English (US)",
volume = "59",
pages = "367--371",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "5",

}

TY - JOUR

T1 - Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma

AU - Guill, Margaret Frank

AU - Maloney, M. J.

AU - DuRant, R. H.

PY - 1987/12/1

Y1 - 1987/12/1

N2 - The separate and combined effects of inhaled metaproterenol and atropine sulfate were evaluated in the treatment of 44 episodes of acute asthma occurring in 35 children ranging in age from 13 months to 13 years. Peak expiratory flow rate and pulmonary index were measured before and after each of up to three inhalation treatments. Significant improvement in peak flow rate (P < .04) was noted after the second inhalation of metaproterenol both with and without the combination of atropine sulfate compared with the effects of atropine alone. Patients treated with metaproterenol and metaproterenol combined with atropine also experienced fewer therapeutic failures (2/15 and 2/16, respectively) compared with those treated with atropine (6/13, P < .02). Pulmonary index scores did not differ among the treatment groups. Inhaled metaproterenol appears to be more effective than inhaled atropine sulfate in the treatment of children with acute asthma. The addition of inhaled atropine sulfate appears to offer no advantage over treatment with inhaled metaproterenol alone.

AB - The separate and combined effects of inhaled metaproterenol and atropine sulfate were evaluated in the treatment of 44 episodes of acute asthma occurring in 35 children ranging in age from 13 months to 13 years. Peak expiratory flow rate and pulmonary index were measured before and after each of up to three inhalation treatments. Significant improvement in peak flow rate (P < .04) was noted after the second inhalation of metaproterenol both with and without the combination of atropine sulfate compared with the effects of atropine alone. Patients treated with metaproterenol and metaproterenol combined with atropine also experienced fewer therapeutic failures (2/15 and 2/16, respectively) compared with those treated with atropine (6/13, P < .02). Pulmonary index scores did not differ among the treatment groups. Inhaled metaproterenol appears to be more effective than inhaled atropine sulfate in the treatment of children with acute asthma. The addition of inhaled atropine sulfate appears to offer no advantage over treatment with inhaled metaproterenol alone.

UR - http://www.scopus.com/inward/record.url?scp=0023510097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023510097&partnerID=8YFLogxK

M3 - Article

C2 - 3318574

AN - SCOPUS:0023510097

VL - 59

SP - 367

EP - 371

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 5

ER -