Compounds of IL-6 Receptor Complex during Acute Lung Injury

D. A. Chepurnova; E. V. Samoilova; A. A. Anisimov; A. D. Verin; A. A. Korotaeva

doi:10.1007/s10517-018-4042-9

Compounds of IL-6 Receptor Complex during Acute Lung Injury

D. A. Chepurnova, E. V. Samoilova, A. A. Anisimov, A. D. Verin, A. A. Korotaeva

Pulmonary

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16 Scopus citations

Abstract

Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

Original language	English (US)
Pages (from-to)	609-611
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	164
Issue number	5
DOIs	https://doi.org/10.1007/s10517-018-4042-9
State	Published - Mar 1 2018

Keywords

acute lung injury
inflammation
sgp130
soluble receptor of IL-6

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/s10517-018-4042-9

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abstract = "Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.",

keywords = "acute lung injury, inflammation, sgp130, soluble receptor of IL-6",

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AU - Chepurnova, D. A.

AU - Samoilova, E. V.

AU - Anisimov, A. A.

AU - Verin, A. D.

AU - Korotaeva, A. A.

N1 - Funding Information: The experiments were supported by the National Institute of Health, USA (grant HL101902) and Russian Foundation of Basic Research (grant No. 16-04-00410). Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2018/3/1

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N2 - Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

AB - Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

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Compounds of IL-6 Receptor Complex during Acute Lung Injury

Abstract

Keywords

ASJC Scopus subject areas

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