Contemporary Management of Pineoblastoma

Matthew C. Tate, Martin J. Rutkowski, Andrew T. Parsa

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Pineoblastomas (PBs) represent the most aggressive of the pineal parenchymal tumors. Routine treatment consists of operative management of obstructive hydrocephalus and cerebrospinal fluid studies followed by maximal resection and adjuvant chemotherapy/radiotherapy, resulting in a median survival of 20 months. Important prognostic factors for survival of patients with PB include extent of resection, age at presentation, disseminated disease, and craniospinal radiotherapy. Novel strategies being evaluated for the treatment of PB include high-dose chemotherapy with autologous stem cell therapy, stereotactic radiosurgery, and histone deacetylase inhibitors.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalNeurosurgery Clinics of North America
Volume22
Issue number3
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Pineoblastoma
  • Survival
  • Treatment

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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