Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster

J. K. Cowell, I. J. Hartmann-Goldstein

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1:4)wm258-21 heterozygotes showed that when the euchromatic region 3D1-E2 is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C1-10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E1-3A4, distal to 3C1 and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.

Original languageEnglish (US)
Pages (from-to)329-340
Number of pages12
JournalChromosoma
Volume79
Issue number3
DOIs
StatePublished - Jul 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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