Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster

J. K. Cowell; I. J. Hartmann-Goldstein

doi:10.1007/BF00327323

Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster

J. K. Cowell, I. J. Hartmann-Goldstein

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Abstract

Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1:4)w^m258-21 heterozygotes showed that when the euchromatic region 3D₁-E₂ is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C_1-10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E₁-3A₄, distal to 3C₁ and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.

Original language	English (US)
Pages (from-to)	329-340
Number of pages	12
Journal	Chromosoma
Volume	79
Issue number	3
DOIs	https://doi.org/10.1007/BF00327323
State	Published - Jul 1 1980
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster",

abstract = "Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1:4)wm258-21 heterozygotes showed that when the euchromatic region 3D1-E2 is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C1-10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E1-3A4, distal to 3C1 and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.",

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AU - Hartmann-Goldstein, I. J.

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N2 - Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1:4)wm258-21 heterozygotes showed that when the euchromatic region 3D1-E2 is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C1-10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E1-3A4, distal to 3C1 and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.

AB - Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1:4)wm258-21 heterozygotes showed that when the euchromatic region 3D1-E2 is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C1-10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E1-3A4, distal to 3C1 and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.

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Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster

Abstract

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