Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility

Alexis Michelle Stranahan, Kim Lee, Mark P. Mattson

Research output: Contribution to journalShort survey

13 Citations (Scopus)

Abstract

Connectivity between the hippocampus and hypothalamus plays an essential role in circadian rhythmicity and stress responsiveness. Both hippocampal dysfunction and loss of hormonal pulsatility have been demonstrated in aged animals, but the possibility of a functional interaction between these two processes remains unexplored. Correlated hippocampal neuropathology and flattening of the circadian rhythms occur in the elderly, and we propose that these processes are causally linked. In this review, we discuss the anatomical and functional nature of hippocampal interconnections with the hypothalamus. We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain.

Original languageEnglish (US)
Pages (from-to)164-176
Number of pages13
JournalAgeing Research Reviews
Volume7
Issue number3
DOIs
StatePublished - Oct 1 2008

Fingerprint

Hypothalamus
Plasticity
Animals
Periodicity
Circadian Rhythm
Hippocampus
Brain
Aging of materials
Neuropathology

Keywords

  • Alzheimer's disease
  • Circadian rhythms
  • Dendritic spines
  • Hypothalamus
  • LTP
  • Neurogenesis
  • Oxidative stress

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility. / Stranahan, Alexis Michelle; Lee, Kim; Mattson, Mark P.

In: Ageing Research Reviews, Vol. 7, No. 3, 01.10.2008, p. 164-176.

Research output: Contribution to journalShort survey

@article{173d9668d3c44fbaaf984502d1ef67d6,
title = "Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility",
abstract = "Connectivity between the hippocampus and hypothalamus plays an essential role in circadian rhythmicity and stress responsiveness. Both hippocampal dysfunction and loss of hormonal pulsatility have been demonstrated in aged animals, but the possibility of a functional interaction between these two processes remains unexplored. Correlated hippocampal neuropathology and flattening of the circadian rhythms occur in the elderly, and we propose that these processes are causally linked. In this review, we discuss the anatomical and functional nature of hippocampal interconnections with the hypothalamus. We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain.",
keywords = "Alzheimer's disease, Circadian rhythms, Dendritic spines, Hypothalamus, LTP, Neurogenesis, Oxidative stress",
author = "Stranahan, {Alexis Michelle} and Kim Lee and Mattson, {Mark P.}",
year = "2008",
month = "10",
day = "1",
doi = "10.1016/j.arr.2007.12.004",
language = "English (US)",
volume = "7",
pages = "164--176",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility

AU - Stranahan, Alexis Michelle

AU - Lee, Kim

AU - Mattson, Mark P.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Connectivity between the hippocampus and hypothalamus plays an essential role in circadian rhythmicity and stress responsiveness. Both hippocampal dysfunction and loss of hormonal pulsatility have been demonstrated in aged animals, but the possibility of a functional interaction between these two processes remains unexplored. Correlated hippocampal neuropathology and flattening of the circadian rhythms occur in the elderly, and we propose that these processes are causally linked. In this review, we discuss the anatomical and functional nature of hippocampal interconnections with the hypothalamus. We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain.

AB - Connectivity between the hippocampus and hypothalamus plays an essential role in circadian rhythmicity and stress responsiveness. Both hippocampal dysfunction and loss of hormonal pulsatility have been demonstrated in aged animals, but the possibility of a functional interaction between these two processes remains unexplored. Correlated hippocampal neuropathology and flattening of the circadian rhythms occur in the elderly, and we propose that these processes are causally linked. In this review, we discuss the anatomical and functional nature of hippocampal interconnections with the hypothalamus. We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain.

KW - Alzheimer's disease

KW - Circadian rhythms

KW - Dendritic spines

KW - Hypothalamus

KW - LTP

KW - Neurogenesis

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=51649120894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649120894&partnerID=8YFLogxK

U2 - 10.1016/j.arr.2007.12.004

DO - 10.1016/j.arr.2007.12.004

M3 - Short survey

C2 - 18262476

AN - SCOPUS:51649120894

VL - 7

SP - 164

EP - 176

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

IS - 3

ER -