Coronary artery disease, myocardial infarction, and brain embolism

David C Hess, I. A. D'Cruz, R. J. Adams, Fenwick T Nichols

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The incidence of in-hospital stroke complicating acute myocardial infarction is approximately 1%. This rate is largely unaffected by thrombolytic therapy. Large myocardial infarctions, anterior wall involvement, prior stroke, and increasing age are risk factors for ischemic stroke. Left ventricular thrombi commonly occur with anterior wall infarctions. There is some evidence that anticoagulation reduces their incidence and uncontrolled studies suggest that anticoagulation may reduce the risk of embolization. Left ventricular aneurysms have a low rate of embolization and do not require systemic anticoagulation. Treatment of acute myocardial infarction with t-PA and anisoylated plasminogen streptokinase activator complex are associated with a higher risk of stroke than treatment with streptokinase; this excess risk is attributable to an increased rate of cerebral hemorrhages.

Original languageEnglish (US)
Pages (from-to)399-417
Number of pages19
JournalNeurologic Clinics
Volume11
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes

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Intracranial Embolism
Coronary Artery Disease
Stroke
Myocardial Infarction
Anistreplase
Anterior Wall Myocardial Infarction
Streptokinase
Age Factors
Thrombolytic Therapy
Cerebral Hemorrhage
Infarction
Aneurysm
Thrombosis
Cohort Studies
Incidence
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Coronary artery disease, myocardial infarction, and brain embolism. / Hess, David C; D'Cruz, I. A.; Adams, R. J.; Nichols, Fenwick T.

In: Neurologic Clinics, Vol. 11, No. 2, 01.01.1993, p. 399-417.

Research output: Contribution to journalReview article

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