Corrosion of phosphate-enriched titanium oxide surface dental implants (TiUnite®) under in vitro infammatory and hyperglycemic conditions

Regina L W Messer, Francesca Seta, John Mickalonis, Yolanda Brown, Jill B. Lewis, John C. Wataha

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Endosseous dental implants use is increasing in patients with systemic conditions that compromise wound healing. Manufacturers recently have redesigned implants to ensure more reliable and faster osseointegration. One design strategy has been to create a porous phosphate-enriched titanium oxide (TiUnite®) surface to increase surface area and enhance interactions with bone. In the current study, the corrosion properties of TiUnite® implants were studied in cultures of monocytic cells and solutions simulating inflammatory and hyperglycemic conditions. Furthermore, to investigate whether placement into bone causes enough mechanical damage to alter implant corrosion properties, the enhanced surface implants as well as machined titanium implants were placed into human cadaver mandibular bone, the bone removed, and the corrosion properties measured. Implant corrosion behavior was characterized by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy. In selected samples, THP1 cells were activated with lipopolysaccharide prior to implant exposure to simulate an inflammatory environment. No significant differences in corrosion potentials were measured between the TiUnite® implants and the machined titanium implants in previous studies. TiUnite® implants exhibited lower corrosion rates in all simulated conditions than observed in PBS, and EIS measurements revealed two time constants which shifted with proteincontaining electrolytes. In addition, the TiUnite® implants displayed a significantly lower corrosion rate than the machined titanium implants after placement into bone. The current study suggests that the corrosion risk of the enhanced oxide implant is lower than its machined surface titanium implant counterpart under simulated conditions of inflammation, elevated dextrose concentrations, and after implantation into bone.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume92
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Dental prostheses
Dental Implants
Corrosion
Titanium oxides
Bone
Phosphates
Titanium
Bone and Bones
Corrosion rate
Dextrose
Acoustic impedance
Dielectric Spectroscopy
Osseointegration
Oxides
Electrolytes
Lipopolysaccharides
Surface Properties
titanium dioxide
In Vitro Techniques
Electric Impedance

Keywords

  • Cell culture
  • Corrosion
  • Titanium (alloys)

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Corrosion of phosphate-enriched titanium oxide surface dental implants (TiUnite®) under in vitro infammatory and hyperglycemic conditions. / Messer, Regina L W; Seta, Francesca; Mickalonis, John; Brown, Yolanda; Lewis, Jill B.; Wataha, John C.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 92, No. 2, 01.02.2010, p. 525-534.

Research output: Contribution to journalArticle

@article{ebb0b0d4a0cd4da58ce173efb6c5a3c3,
title = "Corrosion of phosphate-enriched titanium oxide surface dental implants (TiUnite{\circledR}) under in vitro infammatory and hyperglycemic conditions",
abstract = "Endosseous dental implants use is increasing in patients with systemic conditions that compromise wound healing. Manufacturers recently have redesigned implants to ensure more reliable and faster osseointegration. One design strategy has been to create a porous phosphate-enriched titanium oxide (TiUnite{\circledR}) surface to increase surface area and enhance interactions with bone. In the current study, the corrosion properties of TiUnite{\circledR} implants were studied in cultures of monocytic cells and solutions simulating inflammatory and hyperglycemic conditions. Furthermore, to investigate whether placement into bone causes enough mechanical damage to alter implant corrosion properties, the enhanced surface implants as well as machined titanium implants were placed into human cadaver mandibular bone, the bone removed, and the corrosion properties measured. Implant corrosion behavior was characterized by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy. In selected samples, THP1 cells were activated with lipopolysaccharide prior to implant exposure to simulate an inflammatory environment. No significant differences in corrosion potentials were measured between the TiUnite{\circledR} implants and the machined titanium implants in previous studies. TiUnite{\circledR} implants exhibited lower corrosion rates in all simulated conditions than observed in PBS, and EIS measurements revealed two time constants which shifted with proteincontaining electrolytes. In addition, the TiUnite{\circledR} implants displayed a significantly lower corrosion rate than the machined titanium implants after placement into bone. The current study suggests that the corrosion risk of the enhanced oxide implant is lower than its machined surface titanium implant counterpart under simulated conditions of inflammation, elevated dextrose concentrations, and after implantation into bone.",
keywords = "Cell culture, Corrosion, Titanium (alloys)",
author = "Messer, {Regina L W} and Francesca Seta and John Mickalonis and Yolanda Brown and Lewis, {Jill B.} and Wataha, {John C.}",
year = "2010",
month = "2",
day = "1",
doi = "10.1002/jbm.b.31548",
language = "English (US)",
volume = "92",
pages = "525--534",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "0021-9304",
publisher = "Heterocorporation",
number = "2",

}

TY - JOUR

T1 - Corrosion of phosphate-enriched titanium oxide surface dental implants (TiUnite®) under in vitro infammatory and hyperglycemic conditions

AU - Messer, Regina L W

AU - Seta, Francesca

AU - Mickalonis, John

AU - Brown, Yolanda

AU - Lewis, Jill B.

AU - Wataha, John C.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Endosseous dental implants use is increasing in patients with systemic conditions that compromise wound healing. Manufacturers recently have redesigned implants to ensure more reliable and faster osseointegration. One design strategy has been to create a porous phosphate-enriched titanium oxide (TiUnite®) surface to increase surface area and enhance interactions with bone. In the current study, the corrosion properties of TiUnite® implants were studied in cultures of monocytic cells and solutions simulating inflammatory and hyperglycemic conditions. Furthermore, to investigate whether placement into bone causes enough mechanical damage to alter implant corrosion properties, the enhanced surface implants as well as machined titanium implants were placed into human cadaver mandibular bone, the bone removed, and the corrosion properties measured. Implant corrosion behavior was characterized by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy. In selected samples, THP1 cells were activated with lipopolysaccharide prior to implant exposure to simulate an inflammatory environment. No significant differences in corrosion potentials were measured between the TiUnite® implants and the machined titanium implants in previous studies. TiUnite® implants exhibited lower corrosion rates in all simulated conditions than observed in PBS, and EIS measurements revealed two time constants which shifted with proteincontaining electrolytes. In addition, the TiUnite® implants displayed a significantly lower corrosion rate than the machined titanium implants after placement into bone. The current study suggests that the corrosion risk of the enhanced oxide implant is lower than its machined surface titanium implant counterpart under simulated conditions of inflammation, elevated dextrose concentrations, and after implantation into bone.

AB - Endosseous dental implants use is increasing in patients with systemic conditions that compromise wound healing. Manufacturers recently have redesigned implants to ensure more reliable and faster osseointegration. One design strategy has been to create a porous phosphate-enriched titanium oxide (TiUnite®) surface to increase surface area and enhance interactions with bone. In the current study, the corrosion properties of TiUnite® implants were studied in cultures of monocytic cells and solutions simulating inflammatory and hyperglycemic conditions. Furthermore, to investigate whether placement into bone causes enough mechanical damage to alter implant corrosion properties, the enhanced surface implants as well as machined titanium implants were placed into human cadaver mandibular bone, the bone removed, and the corrosion properties measured. Implant corrosion behavior was characterized by open circuit potentials, linear polarization resistance, and electrical impedance spectroscopy. In selected samples, THP1 cells were activated with lipopolysaccharide prior to implant exposure to simulate an inflammatory environment. No significant differences in corrosion potentials were measured between the TiUnite® implants and the machined titanium implants in previous studies. TiUnite® implants exhibited lower corrosion rates in all simulated conditions than observed in PBS, and EIS measurements revealed two time constants which shifted with proteincontaining electrolytes. In addition, the TiUnite® implants displayed a significantly lower corrosion rate than the machined titanium implants after placement into bone. The current study suggests that the corrosion risk of the enhanced oxide implant is lower than its machined surface titanium implant counterpart under simulated conditions of inflammation, elevated dextrose concentrations, and after implantation into bone.

KW - Cell culture

KW - Corrosion

KW - Titanium (alloys)

UR - http://www.scopus.com/inward/record.url?scp=74749090137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74749090137&partnerID=8YFLogxK

U2 - 10.1002/jbm.b.31548

DO - 10.1002/jbm.b.31548

M3 - Article

C2 - 20024965

AN - SCOPUS:74749090137

VL - 92

SP - 525

EP - 534

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 0021-9304

IS - 2

ER -