Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics

Y. Sterner, C. Törn, H. S. Lee, H. Larsson, C. Winkler, W. McLeod, K. Lynch, O. Simell, A. Ziegler, D. Schatz, W. Hagopian, M. Rewers, Jin-Xiong She, J. P. Krischer, B. Akolkar, Å Lernmark

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To examine the relationship between high-risk human leukocyte antigen (HLA) genotypes for type 1 diabetes and birth size in combination with prenatal characteristics in different countries. Study Design: Four high-risk HLA genotypes were enrolled in the Environmental determinants of Diabetes in the Young study newborn babies from the general population in Finland, Germany, Sweden and the United States. Stepwise regression analyses were used to adjust for country, parental physical characteristics and environmental factors during pregnancy. Result: Regression analyses did not reveal differences in birth size between the four type 1 diabetes high-risk HLA genotypes. Compared with DQ 4/8 in each country, (1) DQ 2/2 children were heavier in the United States (P=0.028) mostly explained however, by parental weight; (2) DQ 2/8 (P=0.023) and DQ 8/8 (P=0.046) children were longer in Sweden independent of parents height and as well as (3) in the United States for DQ 2/8 (P=0.023), but again dependent on parental height. Conclusion: Children born with type 1 diabetes high-risk HLA genotypes have comparable birth size. Longitudinal follow-up of these children should reveal whether birth size differences between countries contribute to the risk for islet autoimmunity and type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)764-769
Number of pages6
JournalJournal of Perinatology
Volume31
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

HLA Antigens
Type 1 Diabetes Mellitus
Birth Weight
Genotype
Parturition
Sweden
Regression Analysis
Finland
Autoimmunity
Germany
Parents
Newborn Infant
Weights and Measures
Pregnancy
Population

Keywords

  • HLA-DQ
  • geneenvironment interaction
  • parental height
  • parental weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. / Sterner, Y.; Törn, C.; Lee, H. S.; Larsson, H.; Winkler, C.; McLeod, W.; Lynch, K.; Simell, O.; Ziegler, A.; Schatz, D.; Hagopian, W.; Rewers, M.; She, Jin-Xiong; Krischer, J. P.; Akolkar, B.; Lernmark, Å.

In: Journal of Perinatology, Vol. 31, No. 12, 01.12.2011, p. 764-769.

Research output: Contribution to journalArticle

Sterner, Y, Törn, C, Lee, HS, Larsson, H, Winkler, C, McLeod, W, Lynch, K, Simell, O, Ziegler, A, Schatz, D, Hagopian, W, Rewers, M, She, J-X, Krischer, JP, Akolkar, B & Lernmark, Å 2011, 'Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics', Journal of Perinatology, vol. 31, no. 12, pp. 764-769. https://doi.org/10.1038/jp.2011.26
Sterner, Y. ; Törn, C. ; Lee, H. S. ; Larsson, H. ; Winkler, C. ; McLeod, W. ; Lynch, K. ; Simell, O. ; Ziegler, A. ; Schatz, D. ; Hagopian, W. ; Rewers, M. ; She, Jin-Xiong ; Krischer, J. P. ; Akolkar, B. ; Lernmark, Å. / Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. In: Journal of Perinatology. 2011 ; Vol. 31, No. 12. pp. 764-769.
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