COUP-TF-interacting protein-2 (Ctip2): Driving the coupé of sphingolipid biosynthesis in the epidermis

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice have demonstrated the importance of this transcription factor for the formation of the epidermal permeability barrier. Because sphingolipids are crucial in generating the barrier, in this issue Indra and colleagues show, perhaps not surprisingly, that Ctip2 has a key role in sphingolipid metabolism. Thus, Ctip2 gene ablation alters sphingolipid levels and expression of genes encoding sphingolipid- metabolizing enzymes, in some cases by direct binding to their promoters. Abnormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal permeability barrier.

Original languageEnglish (US)
Pages (from-to)593-594
Number of pages2
JournalJournal of Investigative Dermatology
Volume133
Issue number3
DOIs
StatePublished - Jan 1 2013

Fingerprint

COUP Transcription Factors
Sphingolipids
Biosynthesis
Epidermis
Permeability
Proteins
Gene encoding
Ablation
Metabolism
Knockout Mice
Skin
Transcription Factors
Genes
Gene Expression
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

COUP-TF-interacting protein-2 (Ctip2) : Driving the coupé of sphingolipid biosynthesis in the epidermis. / Bollag, Wendy B.

In: Journal of Investigative Dermatology, Vol. 133, No. 3, 01.01.2013, p. 593-594.

Research output: Contribution to journalComment/debate

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abstract = "Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice have demonstrated the importance of this transcription factor for the formation of the epidermal permeability barrier. Because sphingolipids are crucial in generating the barrier, in this issue Indra and colleagues show, perhaps not surprisingly, that Ctip2 has a key role in sphingolipid metabolism. Thus, Ctip2 gene ablation alters sphingolipid levels and expression of genes encoding sphingolipid- metabolizing enzymes, in some cases by direct binding to their promoters. Abnormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal permeability barrier.",
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