Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol

Robert B. Zipursky, Hongbin Gu, Alan I. Green, Diana O. Perkins, Mauricio F. Tohen, Joseph Patrick McEvoy, Stephen M. Strakowski, Tonmoy Sharma, René S. Kahn, Raquel E. Gur, Gary D. Tollefson, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Background: Substantial weight gain is common with many atypical antipsychotics. Aims: To evaluate the extent, time course and predictors of weight gain and its effect on study retention among people with first-episode psychosis treated with olanzapine or haloperidol. Method: Survival analysis assessed time to potentially clinically significant weight gain (≥ 7%) and the effect of weight gain on study retention. Weight gain during the 2-year study was summarised using last-observation-carried-forward (LOCF), observed cases and study completion approaches. Results: After 2 years of treatment, LOCF mean weight gain was 10.2 kg (s.d.=10.1) for olanzapine (n=131) and 4.0 kg (s.d.=7.3) for haloperidol (n=132); observed cases mean weight gain was 15.4 kg (s.d.=10.0) for olanzapine and 7.5 kg (s.d.=9.2) for haloperidol. Change in body mass index was significantly predicted only by treatment group (P < 0.0001). Conclusions: Olanzapine was associated with significantly greater weight gain than haloperidol, with both leading to greater weight gain than previously described.

Original languageEnglish (US)
Pages (from-to)535-543
Number of pages9
JournalBritish Journal of Psychiatry
Volume187
Issue numberDEC.
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Zipursky, R. B., Gu, H., Green, A. I., Perkins, D. O., Tohen, M. F., McEvoy, J. P., Strakowski, S. M., Sharma, T., Kahn, R. S., Gur, R. E., Tollefson, G. D., & Lieberman, J. A. (2005). Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol. British Journal of Psychiatry, 187(DEC.), 535-543. https://doi.org/10.1192/bjp.187.6.537