Craniopharyngioma: A comparison of tumor control with various treatment strategies

Isaac Yang, Michael E. Sughrue, Martin J. Rutkowski, Rajwant Kaur, Michael E. Ivan, Derick Aranda, Igor J. Barani, Andrew T. Parsa

Research output: Contribution to journalArticle

Abstract

Object. Craniopharyngiomas have a propensity to recur after resection, potentially causing death through their aggressive local behavior in their critical site of origin. Recent data suggest that subtotal resection (STR) followed by adjuvant radiotherapy (XRT) may be an appealing substitute for gross-total resection (GTR), providing similar rates of tumor control without the morbidity associated with aggressive resection. Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas. Methods. The authors performed a comprehensive search of the English language literature to identify studies publishing outcome data on patients undergoing surgery for craniopharyngioma. Rates of progression-free survival (PFS) and overall survival (OS) were determined through Kaplan-Meier analysis. Results. There were 442 patients who underwent tumor resection. Among these patients, GTR was achieved in 256 cases (58%), STR in 101 cases (23%), and STR+XRT in 85 cases (19%). The 2- and 5-year PFS rates for the GTR group versus the STR+XRT group were 88 versus 91%, and 67 versus 69%, respectively. The 5- and 10-year OS rates for the GTR group versus the STR+XRT group were 98 versus 99%, and 98 versus 95%, respectively. There was no significant difference in PFS (log-rank test) or OS with GTR (log-rank test). Conclusions. Given the relative rarity of craniopharyngioma, this study provides estimates of outcome for a variety of treatment combinations, as not all treatments are an option for all patients with these tumors.

Original languageEnglish (US)
Pages (from-to)E5.1-E5.11
JournalNeurosurgical focus
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Fingerprint

Craniopharyngioma
Disease-Free Survival
Neoplasms
Survival Rate
Adjuvant Radiotherapy
Survival
Kaplan-Meier Estimate
Therapeutics
Language
Outcome Assessment (Health Care)
Morbidity

Keywords

  • Craniopharyngioma
  • Gross-total resection
  • Radiotherapy
  • Surgery
  • Tumor control

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Yang, I., Sughrue, M. E., Rutkowski, M. J., Kaur, R., Ivan, M. E., Aranda, D., ... Parsa, A. T. (2010). Craniopharyngioma: A comparison of tumor control with various treatment strategies. Neurosurgical focus, 28(4), E5.1-E5.11. https://doi.org/10.3171/2010.1.FOCUS09307

Craniopharyngioma : A comparison of tumor control with various treatment strategies. / Yang, Isaac; Sughrue, Michael E.; Rutkowski, Martin J.; Kaur, Rajwant; Ivan, Michael E.; Aranda, Derick; Barani, Igor J.; Parsa, Andrew T.

In: Neurosurgical focus, Vol. 28, No. 4, 01.04.2010, p. E5.1-E5.11.

Research output: Contribution to journalArticle

Yang, I, Sughrue, ME, Rutkowski, MJ, Kaur, R, Ivan, ME, Aranda, D, Barani, IJ & Parsa, AT 2010, 'Craniopharyngioma: A comparison of tumor control with various treatment strategies', Neurosurgical focus, vol. 28, no. 4, pp. E5.1-E5.11. https://doi.org/10.3171/2010.1.FOCUS09307
Yang I, Sughrue ME, Rutkowski MJ, Kaur R, Ivan ME, Aranda D et al. Craniopharyngioma: A comparison of tumor control with various treatment strategies. Neurosurgical focus. 2010 Apr 1;28(4):E5.1-E5.11. https://doi.org/10.3171/2010.1.FOCUS09307
Yang, Isaac ; Sughrue, Michael E. ; Rutkowski, Martin J. ; Kaur, Rajwant ; Ivan, Michael E. ; Aranda, Derick ; Barani, Igor J. ; Parsa, Andrew T. / Craniopharyngioma : A comparison of tumor control with various treatment strategies. In: Neurosurgical focus. 2010 ; Vol. 28, No. 4. pp. E5.1-E5.11.
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abstract = "Object. Craniopharyngiomas have a propensity to recur after resection, potentially causing death through their aggressive local behavior in their critical site of origin. Recent data suggest that subtotal resection (STR) followed by adjuvant radiotherapy (XRT) may be an appealing substitute for gross-total resection (GTR), providing similar rates of tumor control without the morbidity associated with aggressive resection. Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas. Methods. The authors performed a comprehensive search of the English language literature to identify studies publishing outcome data on patients undergoing surgery for craniopharyngioma. Rates of progression-free survival (PFS) and overall survival (OS) were determined through Kaplan-Meier analysis. Results. There were 442 patients who underwent tumor resection. Among these patients, GTR was achieved in 256 cases (58{\%}), STR in 101 cases (23{\%}), and STR+XRT in 85 cases (19{\%}). The 2- and 5-year PFS rates for the GTR group versus the STR+XRT group were 88 versus 91{\%}, and 67 versus 69{\%}, respectively. The 5- and 10-year OS rates for the GTR group versus the STR+XRT group were 98 versus 99{\%}, and 98 versus 95{\%}, respectively. There was no significant difference in PFS (log-rank test) or OS with GTR (log-rank test). Conclusions. Given the relative rarity of craniopharyngioma, this study provides estimates of outcome for a variety of treatment combinations, as not all treatments are an option for all patients with these tumors.",
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N2 - Object. Craniopharyngiomas have a propensity to recur after resection, potentially causing death through their aggressive local behavior in their critical site of origin. Recent data suggest that subtotal resection (STR) followed by adjuvant radiotherapy (XRT) may be an appealing substitute for gross-total resection (GTR), providing similar rates of tumor control without the morbidity associated with aggressive resection. Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas. Methods. The authors performed a comprehensive search of the English language literature to identify studies publishing outcome data on patients undergoing surgery for craniopharyngioma. Rates of progression-free survival (PFS) and overall survival (OS) were determined through Kaplan-Meier analysis. Results. There were 442 patients who underwent tumor resection. Among these patients, GTR was achieved in 256 cases (58%), STR in 101 cases (23%), and STR+XRT in 85 cases (19%). The 2- and 5-year PFS rates for the GTR group versus the STR+XRT group were 88 versus 91%, and 67 versus 69%, respectively. The 5- and 10-year OS rates for the GTR group versus the STR+XRT group were 98 versus 99%, and 98 versus 95%, respectively. There was no significant difference in PFS (log-rank test) or OS with GTR (log-rank test). Conclusions. Given the relative rarity of craniopharyngioma, this study provides estimates of outcome for a variety of treatment combinations, as not all treatments are an option for all patients with these tumors.

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