Current knowledge: The regenerative potential of periosteum-derived cells and their application in oral and craniofacial therapy

Jacob Kobi Stern, Zheng Zhou, Aaron Rawlings, Solon Ting-Yao Kao, Christopher W Cutler, Hector Rios

Research output: Contribution to journalReview article

Abstract

Different types of adult mesenchymal stem cells (MSCs) have been isolated from numerous tissues and confirmed to acquire specific characteristics and differentiation potency. Over the past few decades, many researchers have reported that the periosteum, an important tissue in embryogenesis, fracture healing, and cartilage repair, contains a population of such cells that mediate the repair of bone defects and could provide cells for osteochondral tissue engineering. Furthermore, recent reports on oral, maxillofacial and orthopedic reconstructive procedures have focused on the periosteum as an ideal source for bone tissue engineering due to its abundance, easy accessibility, superior growth rate and high culture success rate. This manuscript reviews the unique characteristics of periosteum-derived cells (PCs) for tissue engineering purposes and discusses their regenerative potential. In addition, this report summarizes the most recent information and outcomes for various oral and craniofacial reconstructive procedures using PCs in human and animal research published to date. Finally, we discuss the different aspects of using this technology and identify areas for future research.

Original languageEnglish (US)
Pages (from-to)843-860
Number of pages18
JournalJournal of Biomaterials and Tissue Engineering
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Periosteum
Tissue engineering
Tissue Engineering
Bone
Repair
Tissue
Bioelectric potentials
Orthopedics
Cartilage
Orthopedic Procedures
Cell Engineering
Stem cells
Bone and Bones
Adult Stem Cells
Fracture Healing
Animals
Therapeutics
Mesenchymal Stromal Cells
Cells
Embryonic Development

Keywords

  • Bone regeneration
  • Guided tissue regeneration
  • Periosteum
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Current knowledge : The regenerative potential of periosteum-derived cells and their application in oral and craniofacial therapy. / Stern, Jacob Kobi; Zhou, Zheng; Rawlings, Aaron; Kao, Solon Ting-Yao; Cutler, Christopher W; Rios, Hector.

In: Journal of Biomaterials and Tissue Engineering, Vol. 6, No. 11, 01.11.2016, p. 843-860.

Research output: Contribution to journalReview article

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