Cutaneous vascular anomalies associated with neural tube defects: Nomenclature and pathology revisited

Todd Maugans, Rachel M. Sheridan, Denise Adams, Anita Gupta

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Lumbosacral cutaneous vascular anomalies associated with neural tube defects are frequently described in the literature as "hemangiomas. " The classification system for pediatric vascular anomalies developed by the International Society for the Study of Vascular Anomalies provides a framework to accurately diagnose these lesions. OBJECTIVE: To apply this classification to vascular cutaneous anomalies overlying myelodysplasias. METHODS: A retrospective analysis of patients with neural tube defects and lumbosacral cutaneous vascular lesions was performed. All eligible patients had detailed histopathologic analysis of skin and spinal cord/placode lesions. Clinical and radiologic features were analyzed. Conventional histology and GLUT-1 immunostaining were performed to differentiate infantile capillary hemangiomas from capillary vascular malformations. RESULTS: Ten cases with cutaneous lesions associated with neural tube defects were reviewed. Five lesions were diagnosed as infantile capillary hemangiomas based upon histology and positive GLUT-1 endothelial reactivity. These lesions had a strong association with dermal sinus tracts. No reoperations were required for residual intraspinal vascular lesions, and overlying cutaneous vascular anomalies involuted with time. The remaining 5 lesions were diagnosed as capillary malformations. These occurred with both open and closed neural tube defects, did not involute, and demonstrated enlargement and darkening due to vascular congestion. CONCLUSION: The International Society for the Study of Vascular Anomalies scheme should be used to describe the cutaneous vascular lesions associated with neural tube defects: infantile capillary hemangiomas and capillary malformations. We advocate that these lesions be described as "vascular anomalies" or "stains" pending accurate diagnosis by clinical, histological, and immunohistochemical evaluations.

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalNeurosurgery
Volume69
Issue number1
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Fingerprint

Neural Tube Defects
Terminology
Blood Vessels
Pathology
Skin
Histology
Spina Bifida Occulta
Vascular Malformations
Hemangioma
Reoperation
Spinal Cord
Coloring Agents
Pediatrics

Keywords

  • Capillary malformation
  • Cutaneous vascular anomalies
  • Infantile capillary hemangioma
  • Neural tube defect

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Cutaneous vascular anomalies associated with neural tube defects : Nomenclature and pathology revisited. / Maugans, Todd; Sheridan, Rachel M.; Adams, Denise; Gupta, Anita.

In: Neurosurgery, Vol. 69, No. 1, 01.07.2011, p. 112-118.

Research output: Contribution to journalArticle

Maugans, Todd ; Sheridan, Rachel M. ; Adams, Denise ; Gupta, Anita. / Cutaneous vascular anomalies associated with neural tube defects : Nomenclature and pathology revisited. In: Neurosurgery. 2011 ; Vol. 69, No. 1. pp. 112-118.
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