Cytogenetic changes in Wilms' tumors

Virginia Solis, Jon Pritchard, John Kenneth Cowell

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Cytogenetic analysis of 20 Wilms' tumors using short-term culture techniques were undertaken. Chromosome abnormalities were detected in all tumors. In 19 of 20 cases only minor karyotypic changes were observed within cells with near-diploid chromosome numbers; only one tumor was predominantly hyperdiploid. Rearrangements involving chromosome 1 were the most frequently observed abnormality (in 25%) and often resulted in partial or complete trisomy for the long arm. In 20% of the tumors, abnormalities involving chromosomes 11 and 16 were present. The only other chromosomes frequently involved in structural or numerical changes were #12, and #18. Two discrete tumor foci within the same kidney differed cytogenetically, suggesting an independent origin for each focus. No correlation could be made between specific chromosome abnormalities and tumor stage or histologic subtype. Although constitutional deletion of chromosome region 11p13 has frequently been reported to predispose to Wilms' tumor formation, only two tumors with deletions involving this region were observed. Chromosomes from tumors treated with chemotherapy prior to surgical removal and culture yielded findings similar to those in untreated tumor cells.

Original languageEnglish (US)
Pages (from-to)223-234
Number of pages12
JournalCancer Genetics and Cytogenetics
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Wilms Tumor
Cytogenetics
Neoplasms
Chromosomes
Chromosome Aberrations
Chromosomes, Human, Pair 16
Culture Techniques
Chromosome Deletion
Chromosomes, Human, Pair 11
Polyploidy
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Trisomy
Diploidy
Kidney
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic changes in Wilms' tumors. / Solis, Virginia; Pritchard, Jon; Cowell, John Kenneth.

In: Cancer Genetics and Cytogenetics, Vol. 34, No. 2, 01.01.1988, p. 223-234.

Research output: Contribution to journalArticle

Solis, Virginia ; Pritchard, Jon ; Cowell, John Kenneth. / Cytogenetic changes in Wilms' tumors. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 34, No. 2. pp. 223-234.
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