Cytoplasmic and nuclear inheritance of resistance to alkylguanidines and ethidium bromide in a petite-negative yeast

Aurora Brunner, J. Mas, E. Celis, J. R. Mattoon

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Mutants of the petite-negative yeast, Kluyveromyceslactis, resistant to the inhibitors of oxidative phosphorylation, decamethylenediguanidine and octylguanidine were isolated from medium containing ethidium bromide. All mutants were resistant to ethidium bromide; some mutants were resistant to both alkylguanidines, some to one, others to neither. Both nuclear and cytoplasmic inheritance of resistance to decamethylenediguanidine and ethidium bromide was demonstrated by tetrad analysis.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jul 17 1973
Externally publishedYes


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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