Cytoskeletal regulation of nitric oxide synthase

Yunchao Su, Dmitry Yuryevich Kondrikov, Edward R. Block

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

Original languageEnglish (US)
Pages (from-to)439-449
Number of pages11
JournalCell Biochemistry and Biophysics
Volume43
Issue number3
DOIs
StatePublished - Nov 1 2005

Fingerprint

Nitric Oxide Synthase
Nitric Oxide
Cytoskeleton
Nitric Oxide Synthase Type III
Nitric oxide
Nitric Oxide Synthase Type II
Actins
Shear stress
Protein Isoforms
Intermediate Filaments
Polymerization
Actin Cytoskeleton
Microtubules
Pharmaceutical Preparations
Hypoxia

Keywords

  • Actin
  • Endothelium
  • Intermediate filaments
  • Microtubules
  • Transcription

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Biophysics

Cite this

Cytoskeletal regulation of nitric oxide synthase. / Su, Yunchao; Kondrikov, Dmitry Yuryevich; Block, Edward R.

In: Cell Biochemistry and Biophysics, Vol. 43, No. 3, 01.11.2005, p. 439-449.

Research output: Contribution to journalReview article

Su, Yunchao ; Kondrikov, Dmitry Yuryevich ; Block, Edward R. / Cytoskeletal regulation of nitric oxide synthase. In: Cell Biochemistry and Biophysics. 2005 ; Vol. 43, No. 3. pp. 439-449.
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