Cytoskeletal regulation of nitric oxide synthase

Yunchao Su, Dmitry Kondrikov, Edward R. Block

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

The three isoforms of nitric oxide synthase (NOS) - endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS) - colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

Original languageEnglish (US)
Pages (from-to)439-449
Number of pages11
JournalCell Biochemistry and Biophysics
Volume43
Issue number3
DOIs
StatePublished - Nov 1 2005

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Keywords

  • Actin
  • Endothelium
  • Intermediate filaments
  • Microtubules
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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