Dasatinib treatment for philadelphia chromosome-positive leukemias

Francois Guilhot, Timothy P. Hughes, Dong Wook Kim, Jorge E. Cortes, Hanna Jean Khoury

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or - intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with durable treatment responses in all phases of the disease and was well tolerated. For this article, the authors reviewed available information on specific side effects associated with the use of dasatinib. On the basis of more than 2 years' experience of dasatinib treatment during clinical trials, they provide practical recommendations for side-effect management.

Original languageEnglish (US)
Pages (from-to)1381-1394
Number of pages14
JournalCancer
Volume115
Issue number7
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

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Keywords

  • Chronic myeloid leukemia
  • Dasatinib
  • Imatinib
  • Side effects

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Guilhot, F., Hughes, T. P., Kim, D. W., Cortes, J. E., & Khoury, H. J. (2009). Dasatinib treatment for philadelphia chromosome-positive leukemias. Cancer, 115(7), 1381-1394. https://doi.org/10.1002/cncr.24155