Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients

Sahebarao P. Mahadik, Sukdeb Mukherjee, Chandramohan G. Wakade, Heljo Laev, Ravinder R. Reddy, David B. Schnur

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Relative to those from normal subjects, cultured skin fibroblasts from schizophrenic patients have been found to show abnormal growth characteristics and morphology. This study compared skin fibroblasts from 10 drug-free schizophrenic patients and 10 normal control subjects on cell adhesiveness to the substratum. Relative to fibroblasts from normal controls, those from patients showed significantly decreased cell adhesiveness, with no overlap in distribution between the groups. Since fibronectin, a major cell surface molecule, is known to be involved in the fibroblast adhesion to substratum, its extracellular and intracellular distribution was determined by immunocytochemical analysis. Both extracellular and intracellular levels of fibronectin were significantly lower, and the distribution was altered in fibroblasts from the patients.

Original languageEnglish (US)
Pages (from-to)87-97
Number of pages11
JournalPsychiatry Research
Volume53
Issue number1
DOIs
StatePublished - Jan 1 1994

Fingerprint

Adhesiveness
Fibronectins
Fibroblasts
Skin
Growth
Pharmaceutical Preparations

Keywords

  • Schizophrenia
  • fibronectin
  • skin fibroblasts

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients. / Mahadik, Sahebarao P.; Mukherjee, Sukdeb; Wakade, Chandramohan G.; Laev, Heljo; Reddy, Ravinder R.; Schnur, David B.

In: Psychiatry Research, Vol. 53, No. 1, 01.01.1994, p. 87-97.

Research output: Contribution to journalArticle

Mahadik, Sahebarao P. ; Mukherjee, Sukdeb ; Wakade, Chandramohan G. ; Laev, Heljo ; Reddy, Ravinder R. ; Schnur, David B. / Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients. In: Psychiatry Research. 1994 ; Vol. 53, No. 1. pp. 87-97.
@article{8b8db0c747504ce8b2323d3093e96a9e,
title = "Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients",
abstract = "Relative to those from normal subjects, cultured skin fibroblasts from schizophrenic patients have been found to show abnormal growth characteristics and morphology. This study compared skin fibroblasts from 10 drug-free schizophrenic patients and 10 normal control subjects on cell adhesiveness to the substratum. Relative to fibroblasts from normal controls, those from patients showed significantly decreased cell adhesiveness, with no overlap in distribution between the groups. Since fibronectin, a major cell surface molecule, is known to be involved in the fibroblast adhesion to substratum, its extracellular and intracellular distribution was determined by immunocytochemical analysis. Both extracellular and intracellular levels of fibronectin were significantly lower, and the distribution was altered in fibroblasts from the patients.",
keywords = "Schizophrenia, fibronectin, skin fibroblasts",
author = "Mahadik, {Sahebarao P.} and Sukdeb Mukherjee and Wakade, {Chandramohan G.} and Heljo Laev and Reddy, {Ravinder R.} and Schnur, {David B.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1016/0165-1781(94)90097-3",
language = "English (US)",
volume = "53",
pages = "87--97",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients

AU - Mahadik, Sahebarao P.

AU - Mukherjee, Sukdeb

AU - Wakade, Chandramohan G.

AU - Laev, Heljo

AU - Reddy, Ravinder R.

AU - Schnur, David B.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Relative to those from normal subjects, cultured skin fibroblasts from schizophrenic patients have been found to show abnormal growth characteristics and morphology. This study compared skin fibroblasts from 10 drug-free schizophrenic patients and 10 normal control subjects on cell adhesiveness to the substratum. Relative to fibroblasts from normal controls, those from patients showed significantly decreased cell adhesiveness, with no overlap in distribution between the groups. Since fibronectin, a major cell surface molecule, is known to be involved in the fibroblast adhesion to substratum, its extracellular and intracellular distribution was determined by immunocytochemical analysis. Both extracellular and intracellular levels of fibronectin were significantly lower, and the distribution was altered in fibroblasts from the patients.

AB - Relative to those from normal subjects, cultured skin fibroblasts from schizophrenic patients have been found to show abnormal growth characteristics and morphology. This study compared skin fibroblasts from 10 drug-free schizophrenic patients and 10 normal control subjects on cell adhesiveness to the substratum. Relative to fibroblasts from normal controls, those from patients showed significantly decreased cell adhesiveness, with no overlap in distribution between the groups. Since fibronectin, a major cell surface molecule, is known to be involved in the fibroblast adhesion to substratum, its extracellular and intracellular distribution was determined by immunocytochemical analysis. Both extracellular and intracellular levels of fibronectin were significantly lower, and the distribution was altered in fibroblasts from the patients.

KW - Schizophrenia

KW - fibronectin

KW - skin fibroblasts

UR - http://www.scopus.com/inward/record.url?scp=0028017615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028017615&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(94)90097-3

DO - 10.1016/0165-1781(94)90097-3

M3 - Article

VL - 53

SP - 87

EP - 97

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -