Decreased penile erection in doca-salt and stroke prone-spontaneously hypertensive rats

K. Chitaley, R Clinton Webb, A. M. Dorrance, T. M. Mills

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Numerous etiological studies have established a positive clinical association between hypertension and erectile dysfunction. However, to date, the mechanism underlying this dysfunction remains to be established. In this study, we demonstrate the presence of erectile dysfunction in two rat models of hypertension, and hypothesize that increased vasoconstrictor signaling via Rho-kinase contributes to the decreased erectile response. We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure/mean arterial pressure (ICP/MAP) upon electrical stimulation of the major pelvic ganglion. As previously shown, inhibition of Rho-kinase activity by intracavernosal injection of the selective inhibitor, Y-27632, resulted in an increase in ICP/MAP. However, Y-27632 was significantly less effective at increasing ICP/MAP in the hypertensive as compared to normotensive rats. Additionally, intracavernosal injection of Y-27632 potentiated the voltage-stimulated increase in ICP/MAP in both hypertensive and normotensive rats, but was less effective at potentiating the voltage-mediated erectile response in the hypertensive rats. Altogether, our data demonstrate a decreased erectile response in a mineralocorticoid and genetic model of hypertension, and suggest the role of increased cell signaling by Rho-kinase in the vasoconstrictor activity of erectile dysfunction associated with hypertension.

Original languageEnglish (US)
Pages (from-to)S16-S20
JournalInternational Journal of Impotence Research
Volume13
DOIs
StatePublished - Jan 1 2001

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Desoxycorticosterone Acetate
Penile Erection
Inbred SHR Rats
rho-Associated Kinases
Arterial Pressure
Erectile Dysfunction
Salts
Stroke
Hypertension
Pressure
Vasoconstrictor Agents
Desoxycorticosterone
Mineralocorticoids
Injections
Genetic Models
Ganglia
Electric Stimulation
Y 27632

Keywords

  • Deoxycorticosterone
  • Erectile dysfunction
  • Hypertension
  • Stroke prone SHR

ASJC Scopus subject areas

  • Urology

Cite this

Decreased penile erection in doca-salt and stroke prone-spontaneously hypertensive rats. / Chitaley, K.; Webb, R Clinton; Dorrance, A. M.; Mills, T. M.

In: International Journal of Impotence Research, Vol. 13, 01.01.2001, p. S16-S20.

Research output: Contribution to journalArticle

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