Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

Ruiben Feng, Claire Rampon, Ya Ping Tang, David Shrom, Janice Jin, Maureen Kyin, Bryce Sopher, George M. Martin, Seong Hun Kim, Ronald B. Langdon, Sangram S. Sisodia, Joe Z. Tsien

Research output: Contribution to journalArticle

373 Citations (Scopus)

Abstract

To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grew normally, but they exhibited a pronounced deficiency in enrichment-induced neurogenesis in the dentate gyrus. This reduction in neurogenesis did not result in appreciable learning deficits, indicating that addition of new neurons is not required for memory formation. However, our postlearning enrichment experiments lead us to postulate that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories. A chronic, abnormal clearance process in the hippocampus may conceivably lead to memory disorders in the mammalian brain.

Original languageEnglish (US)
Pages (from-to)911-926
Number of pages16
JournalNeuron
Volume32
Issue number5
DOIs
StatePublished - Dec 6 2001

Fingerprint

Presenilin-1
Neurogenesis
Prosencephalon
Knockout Mice
Hippocampus
Neurons
Dentate Gyrus
Memory Disorders
Learning
Brain
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. / Feng, Ruiben; Rampon, Claire; Tang, Ya Ping; Shrom, David; Jin, Janice; Kyin, Maureen; Sopher, Bryce; Martin, George M.; Kim, Seong Hun; Langdon, Ronald B.; Sisodia, Sangram S.; Tsien, Joe Z.

In: Neuron, Vol. 32, No. 5, 06.12.2001, p. 911-926.

Research output: Contribution to journalArticle

Feng, R, Rampon, C, Tang, YP, Shrom, D, Jin, J, Kyin, M, Sopher, B, Martin, GM, Kim, SH, Langdon, RB, Sisodia, SS & Tsien, JZ 2001, 'Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces', Neuron, vol. 32, no. 5, pp. 911-926. https://doi.org/10.1016/S0896-6273(01)00523-2
Feng, Ruiben ; Rampon, Claire ; Tang, Ya Ping ; Shrom, David ; Jin, Janice ; Kyin, Maureen ; Sopher, Bryce ; Martin, George M. ; Kim, Seong Hun ; Langdon, Ronald B. ; Sisodia, Sangram S. ; Tsien, Joe Z. / Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. In: Neuron. 2001 ; Vol. 32, No. 5. pp. 911-926.
@article{fb0ef5b7442f45729e3e97947209efd5,
title = "Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces",
abstract = "To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grew normally, but they exhibited a pronounced deficiency in enrichment-induced neurogenesis in the dentate gyrus. This reduction in neurogenesis did not result in appreciable learning deficits, indicating that addition of new neurons is not required for memory formation. However, our postlearning enrichment experiments lead us to postulate that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories. A chronic, abnormal clearance process in the hippocampus may conceivably lead to memory disorders in the mammalian brain.",
author = "Ruiben Feng and Claire Rampon and Tang, {Ya Ping} and David Shrom and Janice Jin and Maureen Kyin and Bryce Sopher and Martin, {George M.} and Kim, {Seong Hun} and Langdon, {Ronald B.} and Sisodia, {Sangram S.} and Tsien, {Joe Z.}",
year = "2001",
month = "12",
day = "6",
doi = "10.1016/S0896-6273(01)00523-2",
language = "English (US)",
volume = "32",
pages = "911--926",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

AU - Feng, Ruiben

AU - Rampon, Claire

AU - Tang, Ya Ping

AU - Shrom, David

AU - Jin, Janice

AU - Kyin, Maureen

AU - Sopher, Bryce

AU - Martin, George M.

AU - Kim, Seong Hun

AU - Langdon, Ronald B.

AU - Sisodia, Sangram S.

AU - Tsien, Joe Z.

PY - 2001/12/6

Y1 - 2001/12/6

N2 - To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grew normally, but they exhibited a pronounced deficiency in enrichment-induced neurogenesis in the dentate gyrus. This reduction in neurogenesis did not result in appreciable learning deficits, indicating that addition of new neurons is not required for memory formation. However, our postlearning enrichment experiments lead us to postulate that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories. A chronic, abnormal clearance process in the hippocampus may conceivably lead to memory disorders in the mammalian brain.

AB - To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grew normally, but they exhibited a pronounced deficiency in enrichment-induced neurogenesis in the dentate gyrus. This reduction in neurogenesis did not result in appreciable learning deficits, indicating that addition of new neurons is not required for memory formation. However, our postlearning enrichment experiments lead us to postulate that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories. A chronic, abnormal clearance process in the hippocampus may conceivably lead to memory disorders in the mammalian brain.

UR - http://www.scopus.com/inward/record.url?scp=18244391974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18244391974&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(01)00523-2

DO - 10.1016/S0896-6273(01)00523-2

M3 - Article

C2 - 11738035

AN - SCOPUS:18244391974

VL - 32

SP - 911

EP - 926

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -