Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus

Yong Li, Jimok Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effects of cannabinoids are mostly mediated by two types of cannabinoid receptors-CB1 receptors in the nervous system and CB2 receptors in the immune system. However, CB2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. The deletion of CB2 receptors in mice induces long-term memory deficits and schizophrenia-like behaviors, implying that endogenous activity of CB2 receptors might be involved in neuropsychiatric effects. Little is known about the cellular mechanisms by which physiological activation of CB2 receptors modulates neuronal functions. We aimed to determine how deletion of CB2 receptors in mice affects synaptic transmission and plasticity. Electrophysiological and morphological studies indicated that CB2 receptor knockout resulted in decreases in excitatory synaptic transmission, long-term potentiation, and dendritic spine density in the hippocampus. Our data imply that endogenous activity of CB2 receptors might contribute to the maintenance of synaptic functions and the expression of normal long-term potentiation. This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalHippocampus
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Cannabinoid Receptor CB2
Long-Term Potentiation
Synaptic Transmission
Hippocampus
Cannabinoid Receptor CB1
Long-Term Memory
Dendritic Spines
Neuronal Plasticity
Cannabinoids
Memory Disorders
Cognition
Nervous System
Immune System
Schizophrenia
Maintenance

Keywords

  • Confocal imaging
  • Dendritic spine
  • Electrophysiology
  • Knockout mouse
  • Memory

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. / Li, Yong; Kim, Jimok.

In: Hippocampus, Vol. 26, No. 3, 01.03.2016, p. 275-281.

Research output: Contribution to journalArticle

@article{397b201634fa433da3036e6086453bda,
title = "Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus",
abstract = "The effects of cannabinoids are mostly mediated by two types of cannabinoid receptors-CB1 receptors in the nervous system and CB2 receptors in the immune system. However, CB2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. The deletion of CB2 receptors in mice induces long-term memory deficits and schizophrenia-like behaviors, implying that endogenous activity of CB2 receptors might be involved in neuropsychiatric effects. Little is known about the cellular mechanisms by which physiological activation of CB2 receptors modulates neuronal functions. We aimed to determine how deletion of CB2 receptors in mice affects synaptic transmission and plasticity. Electrophysiological and morphological studies indicated that CB2 receptor knockout resulted in decreases in excitatory synaptic transmission, long-term potentiation, and dendritic spine density in the hippocampus. Our data imply that endogenous activity of CB2 receptors might contribute to the maintenance of synaptic functions and the expression of normal long-term potentiation. This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.",
keywords = "Confocal imaging, Dendritic spine, Electrophysiology, Knockout mouse, Memory",
author = "Yong Li and Jimok Kim",
year = "2016",
month = "3",
day = "1",
doi = "10.1002/hipo.22558",
language = "English (US)",
volume = "26",
pages = "275--281",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus

AU - Li, Yong

AU - Kim, Jimok

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The effects of cannabinoids are mostly mediated by two types of cannabinoid receptors-CB1 receptors in the nervous system and CB2 receptors in the immune system. However, CB2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. The deletion of CB2 receptors in mice induces long-term memory deficits and schizophrenia-like behaviors, implying that endogenous activity of CB2 receptors might be involved in neuropsychiatric effects. Little is known about the cellular mechanisms by which physiological activation of CB2 receptors modulates neuronal functions. We aimed to determine how deletion of CB2 receptors in mice affects synaptic transmission and plasticity. Electrophysiological and morphological studies indicated that CB2 receptor knockout resulted in decreases in excitatory synaptic transmission, long-term potentiation, and dendritic spine density in the hippocampus. Our data imply that endogenous activity of CB2 receptors might contribute to the maintenance of synaptic functions and the expression of normal long-term potentiation. This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.

AB - The effects of cannabinoids are mostly mediated by two types of cannabinoid receptors-CB1 receptors in the nervous system and CB2 receptors in the immune system. However, CB2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. The deletion of CB2 receptors in mice induces long-term memory deficits and schizophrenia-like behaviors, implying that endogenous activity of CB2 receptors might be involved in neuropsychiatric effects. Little is known about the cellular mechanisms by which physiological activation of CB2 receptors modulates neuronal functions. We aimed to determine how deletion of CB2 receptors in mice affects synaptic transmission and plasticity. Electrophysiological and morphological studies indicated that CB2 receptor knockout resulted in decreases in excitatory synaptic transmission, long-term potentiation, and dendritic spine density in the hippocampus. Our data imply that endogenous activity of CB2 receptors might contribute to the maintenance of synaptic functions and the expression of normal long-term potentiation. This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long-term memory.

KW - Confocal imaging

KW - Dendritic spine

KW - Electrophysiology

KW - Knockout mouse

KW - Memory

UR - http://www.scopus.com/inward/record.url?scp=84958928412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958928412&partnerID=8YFLogxK

U2 - 10.1002/hipo.22558

DO - 10.1002/hipo.22558

M3 - Article

C2 - 26663094

AN - SCOPUS:84958928412

VL - 26

SP - 275

EP - 281

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 3

ER -