Dementia associated with dorsal midbrain lesion

K. J. Meador, D. W. Loring, K. D. Sethi, F. Yaghmai, S. D. Styren, S. T. DeKosky

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although the dorsal midbrain has been implicated in cognitive processes in animals, its role in humans is unclear We report the neuropsychological and postmortem neuropathological findings of a 52-yr-old university professor who developed a profound dementia in association with a focal dorsal midbrain lesion. The patient's disorder appeared to result from a tuberculous granuloma based on the clinical course and autopsy results. Neuropsychologically, he exhibited a generalized impairment across most of the cognitive domains assessed. His deficits were not explained by impaired arousal, specific sensory or motor defects, depression, or hydrocephalus. Although there are inherent limitations to a single-case investigation, our observations are consistent with animal studies that have demonstrated that focal dorsal midbrain lesions may result in cognitive impairment. We propose that the dorsal midbrain is involved in cognitive processing via modulation of thalamocortical networks.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume2
Issue number4
StatePublished - Jan 1 1996

Fingerprint

Mesencephalon
Dementia
Hydrocephalus
Arousal
Granuloma
Autopsy
Depression

Keywords

  • Dementia
  • Mesencephalon
  • Midbrain
  • Truberculosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Meador, K. J., Loring, D. W., Sethi, K. D., Yaghmai, F., Styren, S. D., & DeKosky, S. T. (1996). Dementia associated with dorsal midbrain lesion. Journal of the International Neuropsychological Society, 2(4), 359-367.

Dementia associated with dorsal midbrain lesion. / Meador, K. J.; Loring, D. W.; Sethi, K. D.; Yaghmai, F.; Styren, S. D.; DeKosky, S. T.

In: Journal of the International Neuropsychological Society, Vol. 2, No. 4, 01.01.1996, p. 359-367.

Research output: Contribution to journalArticle

Meador, KJ, Loring, DW, Sethi, KD, Yaghmai, F, Styren, SD & DeKosky, ST 1996, 'Dementia associated with dorsal midbrain lesion', Journal of the International Neuropsychological Society, vol. 2, no. 4, pp. 359-367.
Meador KJ, Loring DW, Sethi KD, Yaghmai F, Styren SD, DeKosky ST. Dementia associated with dorsal midbrain lesion. Journal of the International Neuropsychological Society. 1996 Jan 1;2(4):359-367.
Meador, K. J. ; Loring, D. W. ; Sethi, K. D. ; Yaghmai, F. ; Styren, S. D. ; DeKosky, S. T. / Dementia associated with dorsal midbrain lesion. In: Journal of the International Neuropsychological Society. 1996 ; Vol. 2, No. 4. pp. 359-367.
@article{26cc5a08236a44efac0ea611e5584e8f,
title = "Dementia associated with dorsal midbrain lesion",
abstract = "Although the dorsal midbrain has been implicated in cognitive processes in animals, its role in humans is unclear We report the neuropsychological and postmortem neuropathological findings of a 52-yr-old university professor who developed a profound dementia in association with a focal dorsal midbrain lesion. The patient's disorder appeared to result from a tuberculous granuloma based on the clinical course and autopsy results. Neuropsychologically, he exhibited a generalized impairment across most of the cognitive domains assessed. His deficits were not explained by impaired arousal, specific sensory or motor defects, depression, or hydrocephalus. Although there are inherent limitations to a single-case investigation, our observations are consistent with animal studies that have demonstrated that focal dorsal midbrain lesions may result in cognitive impairment. We propose that the dorsal midbrain is involved in cognitive processing via modulation of thalamocortical networks.",
keywords = "Dementia, Mesencephalon, Midbrain, Truberculosis",
author = "Meador, {K. J.} and Loring, {D. W.} and Sethi, {K. D.} and F. Yaghmai and Styren, {S. D.} and DeKosky, {S. T.}",
year = "1996",
month = "1",
day = "1",
language = "English (US)",
volume = "2",
pages = "359--367",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "4",

}

TY - JOUR

T1 - Dementia associated with dorsal midbrain lesion

AU - Meador, K. J.

AU - Loring, D. W.

AU - Sethi, K. D.

AU - Yaghmai, F.

AU - Styren, S. D.

AU - DeKosky, S. T.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Although the dorsal midbrain has been implicated in cognitive processes in animals, its role in humans is unclear We report the neuropsychological and postmortem neuropathological findings of a 52-yr-old university professor who developed a profound dementia in association with a focal dorsal midbrain lesion. The patient's disorder appeared to result from a tuberculous granuloma based on the clinical course and autopsy results. Neuropsychologically, he exhibited a generalized impairment across most of the cognitive domains assessed. His deficits were not explained by impaired arousal, specific sensory or motor defects, depression, or hydrocephalus. Although there are inherent limitations to a single-case investigation, our observations are consistent with animal studies that have demonstrated that focal dorsal midbrain lesions may result in cognitive impairment. We propose that the dorsal midbrain is involved in cognitive processing via modulation of thalamocortical networks.

AB - Although the dorsal midbrain has been implicated in cognitive processes in animals, its role in humans is unclear We report the neuropsychological and postmortem neuropathological findings of a 52-yr-old university professor who developed a profound dementia in association with a focal dorsal midbrain lesion. The patient's disorder appeared to result from a tuberculous granuloma based on the clinical course and autopsy results. Neuropsychologically, he exhibited a generalized impairment across most of the cognitive domains assessed. His deficits were not explained by impaired arousal, specific sensory or motor defects, depression, or hydrocephalus. Although there are inherent limitations to a single-case investigation, our observations are consistent with animal studies that have demonstrated that focal dorsal midbrain lesions may result in cognitive impairment. We propose that the dorsal midbrain is involved in cognitive processing via modulation of thalamocortical networks.

KW - Dementia

KW - Mesencephalon

KW - Midbrain

KW - Truberculosis

UR - http://www.scopus.com/inward/record.url?scp=0030178112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030178112&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 359

EP - 367

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 4

ER -