Dendritic cell control of tolerogenic responses

Santhakumar Manicassamy, Bali Pulendran

Research output: Contribution to journalReview article

194 Citations (Scopus)

Abstract

One of the most fundamental problems in immunology is the seemingly schizophrenic ability of the immune system to launch robust immunity against pathogens, while acquiring and maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront it every day. A fundamental role for the innate immune system, particularly dendritic cells (DCs), in orchestrating immunological tolerance has been appreciated, but emerging studies have highlighted the nature of the innate receptors and the signaling pathways that program DCs to a tolerogenic state. Furthermore, several studies have emphasized the major role played by cellular interactions and the microenvironment in programming tolerogenic DCs. Here, we review these studies and suggest that the innate control of tolerogenic responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.

Original languageEnglish (US)
Pages (from-to)206-227
Number of pages22
JournalImmunological Reviews
Volume241
Issue number1
DOIs
StatePublished - May 1 2011

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Dendritic Cells
Cellular Microenvironment
Immune System
Allergy and Immunology
Immunity
Antigens
Food

Keywords

  • Dendritic cells
  • Innate immunity
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Dendritic cell control of tolerogenic responses. / Manicassamy, Santhakumar; Pulendran, Bali.

In: Immunological Reviews, Vol. 241, No. 1, 01.05.2011, p. 206-227.

Research output: Contribution to journalReview article

Manicassamy, Santhakumar ; Pulendran, Bali. / Dendritic cell control of tolerogenic responses. In: Immunological Reviews. 2011 ; Vol. 241, No. 1. pp. 206-227.
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