Dental metal allergy in patients with oral, cutaneous, and genital lechenoid reactions

Leigh Ann Scalf, Joseph F. Fowler, Kelli W. Morgan, Stephen Warwick Looney

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: The subject of lichen planus (LP) and dental metal allergy long has been debated. An overwhelming majority of the existing literature focuses on mercury and gold salts in relation to oral lichen planus. Objective: Our objective was to expand current knowledge regarding LP and lichenoid lesions (LL) and dental metal allergy by investigating more metals and investigating cutaneous and genital disease in addition to oral disease. Methods: Fifty-one patients with known LP or LL were patch tested to a series of dental metals. Patients chose to replace their dental metals or make no revision. A telephone survey was conducted after 1 year to determine disease state. Results: Thirty-eight of 51 patients (74.5%) had at least I positive reaction. Twenty-five of 51 patients (49.0%) showed sensitivity to at least 1 mercurial allergen. Prevalence data for patients patch tested by the North American Contact Dermatitis Group (NACDG) from 1996 to 1998 was available for chromate, cobalt, gold, nickel, and thimerosal. The prevalence of positive reactions was higher in our group than in the NACDG group for all 5 of these allergens, and statistical significance was achieved for chromate (P = .028), gold (P = .041), and thimerosal (P = .005). Of patients who had a positive patch test reaction to 1 or more metals, 100% (9 of 9) reported improvement after metal replacement, whereas 62.5% (15 of 24) reported improvement without metal replacement. Conclusion: Sensitization to dental metals is more common among LP and LL patients than in routinely tested patients, and might be an etiologic or triggering factor in the disease.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalUnknown Journal
Volume12
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

allergy
Tooth
Hypersensitivity
Metals
gold
Disease
Skin
Lichen Planus
Group
contact
sensitization
Gold
Thimerosal
Chromates
statistical significance
Contact Dermatitis
telephone
Allergens
Mouth Diseases
Oral Lichen Planus

ASJC Scopus subject areas

  • Dermatology

Cite this

Dental metal allergy in patients with oral, cutaneous, and genital lechenoid reactions. / Scalf, Leigh Ann; Fowler, Joseph F.; Morgan, Kelli W.; Looney, Stephen Warwick.

In: Unknown Journal, Vol. 12, No. 3, 01.01.2001, p. 146-150.

Research output: Contribution to journalArticle

Scalf, Leigh Ann ; Fowler, Joseph F. ; Morgan, Kelli W. ; Looney, Stephen Warwick. / Dental metal allergy in patients with oral, cutaneous, and genital lechenoid reactions. In: Unknown Journal. 2001 ; Vol. 12, No. 3. pp. 146-150.
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abstract = "Background: The subject of lichen planus (LP) and dental metal allergy long has been debated. An overwhelming majority of the existing literature focuses on mercury and gold salts in relation to oral lichen planus. Objective: Our objective was to expand current knowledge regarding LP and lichenoid lesions (LL) and dental metal allergy by investigating more metals and investigating cutaneous and genital disease in addition to oral disease. Methods: Fifty-one patients with known LP or LL were patch tested to a series of dental metals. Patients chose to replace their dental metals or make no revision. A telephone survey was conducted after 1 year to determine disease state. Results: Thirty-eight of 51 patients (74.5{\%}) had at least I positive reaction. Twenty-five of 51 patients (49.0{\%}) showed sensitivity to at least 1 mercurial allergen. Prevalence data for patients patch tested by the North American Contact Dermatitis Group (NACDG) from 1996 to 1998 was available for chromate, cobalt, gold, nickel, and thimerosal. The prevalence of positive reactions was higher in our group than in the NACDG group for all 5 of these allergens, and statistical significance was achieved for chromate (P = .028), gold (P = .041), and thimerosal (P = .005). Of patients who had a positive patch test reaction to 1 or more metals, 100{\%} (9 of 9) reported improvement after metal replacement, whereas 62.5{\%} (15 of 24) reported improvement without metal replacement. Conclusion: Sensitization to dental metals is more common among LP and LL patients than in routinely tested patients, and might be an etiologic or triggering factor in the disease.",
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