Dentin-predentin complex and its permeability

physiologic overview.

D. H. Pashley

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The major channels for solute diffusion across dentin are the dentinal tubules. Since dentin permeation is proportional to the product of tubule number and diameter, both of which increase as the tubules converge on the pulp, we find that dentin permeability increases rapidly as the pulp chamber is approached. The presence of a smear layer of cutting debris on top of cut dentin decreases dentin permeability, especially when permeability is measured by fluid filtration. Further, intratubular material--such as mineral deposits, collagen fibrils, proteoglycan linings, bacteria, etc.--can greatly reduce dentin permeability. Although the presence of irregular or irritation dentin has been thought to greatly reduce dentin permeability, recent in vivo experiments in dogs indicate that the dentin permeability of freshly cut cavities prepared in sound dentin falls very rapidly (i.e., 50-60% in the first six hours) before any histologic changes can be detected, either in the pulp or the dentin. When dogs were depleted of their plasma fibrinogen, this rapid decline in dentin permeability following cavity preparation failed to take place. The results implicate leakage of plasma proteins from the underlying pulpal vessels. The proteins subsequently permeate the tubules, where they are either adsorbed to the tubule walls or physically trapped in such a way as to reduce dentin permeability.

Original languageEnglish (US)
Pages (from-to)613-620
Number of pages8
JournalJournal of Dental Research
Volume64 Spec No
StatePublished - Apr 1 1985

Fingerprint

Dentin Permeability
Dentin
Permeability
Smear Layer
Dogs
Dental Pulp Cavity
Proteoglycans
Fibrinogen
Minerals
Blood Proteins
Collagen
Bacteria

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Dentin-predentin complex and its permeability : physiologic overview. / Pashley, D. H.

In: Journal of Dental Research, Vol. 64 Spec No, 01.04.1985, p. 613-620.

Research output: Contribution to journalArticle

@article{6beba80d572f49e399dd6432a9849afb,
title = "Dentin-predentin complex and its permeability: physiologic overview.",
abstract = "The major channels for solute diffusion across dentin are the dentinal tubules. Since dentin permeation is proportional to the product of tubule number and diameter, both of which increase as the tubules converge on the pulp, we find that dentin permeability increases rapidly as the pulp chamber is approached. The presence of a smear layer of cutting debris on top of cut dentin decreases dentin permeability, especially when permeability is measured by fluid filtration. Further, intratubular material--such as mineral deposits, collagen fibrils, proteoglycan linings, bacteria, etc.--can greatly reduce dentin permeability. Although the presence of irregular or irritation dentin has been thought to greatly reduce dentin permeability, recent in vivo experiments in dogs indicate that the dentin permeability of freshly cut cavities prepared in sound dentin falls very rapidly (i.e., 50-60{\%} in the first six hours) before any histologic changes can be detected, either in the pulp or the dentin. When dogs were depleted of their plasma fibrinogen, this rapid decline in dentin permeability following cavity preparation failed to take place. The results implicate leakage of plasma proteins from the underlying pulpal vessels. The proteins subsequently permeate the tubules, where they are either adsorbed to the tubule walls or physically trapped in such a way as to reduce dentin permeability.",
author = "Pashley, {D. H.}",
year = "1985",
month = "4",
day = "1",
language = "English (US)",
volume = "64 Spec No",
pages = "613--620",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Dentin-predentin complex and its permeability

T2 - physiologic overview.

AU - Pashley, D. H.

PY - 1985/4/1

Y1 - 1985/4/1

N2 - The major channels for solute diffusion across dentin are the dentinal tubules. Since dentin permeation is proportional to the product of tubule number and diameter, both of which increase as the tubules converge on the pulp, we find that dentin permeability increases rapidly as the pulp chamber is approached. The presence of a smear layer of cutting debris on top of cut dentin decreases dentin permeability, especially when permeability is measured by fluid filtration. Further, intratubular material--such as mineral deposits, collagen fibrils, proteoglycan linings, bacteria, etc.--can greatly reduce dentin permeability. Although the presence of irregular or irritation dentin has been thought to greatly reduce dentin permeability, recent in vivo experiments in dogs indicate that the dentin permeability of freshly cut cavities prepared in sound dentin falls very rapidly (i.e., 50-60% in the first six hours) before any histologic changes can be detected, either in the pulp or the dentin. When dogs were depleted of their plasma fibrinogen, this rapid decline in dentin permeability following cavity preparation failed to take place. The results implicate leakage of plasma proteins from the underlying pulpal vessels. The proteins subsequently permeate the tubules, where they are either adsorbed to the tubule walls or physically trapped in such a way as to reduce dentin permeability.

AB - The major channels for solute diffusion across dentin are the dentinal tubules. Since dentin permeation is proportional to the product of tubule number and diameter, both of which increase as the tubules converge on the pulp, we find that dentin permeability increases rapidly as the pulp chamber is approached. The presence of a smear layer of cutting debris on top of cut dentin decreases dentin permeability, especially when permeability is measured by fluid filtration. Further, intratubular material--such as mineral deposits, collagen fibrils, proteoglycan linings, bacteria, etc.--can greatly reduce dentin permeability. Although the presence of irregular or irritation dentin has been thought to greatly reduce dentin permeability, recent in vivo experiments in dogs indicate that the dentin permeability of freshly cut cavities prepared in sound dentin falls very rapidly (i.e., 50-60% in the first six hours) before any histologic changes can be detected, either in the pulp or the dentin. When dogs were depleted of their plasma fibrinogen, this rapid decline in dentin permeability following cavity preparation failed to take place. The results implicate leakage of plasma proteins from the underlying pulpal vessels. The proteins subsequently permeate the tubules, where they are either adsorbed to the tubule walls or physically trapped in such a way as to reduce dentin permeability.

UR - http://www.scopus.com/inward/record.url?scp=0022049257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022049257&partnerID=8YFLogxK

M3 - Article

VL - 64 Spec No

SP - 613

EP - 620

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

ER -