Depressed ventilatory response in oculocraniosomatic neuromuscular disease

James Edwin Carroll, Clifford Zwillich, John V. Weil, Michael H. Brooke

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Four patients with ptosis, external ophthalmoplegia, and ragged-red fibers on muscle biopsy were found to have decreased ventilatory responses to hypoxia and hypercapnia. Respiratory muscle weakness was not responsible for these findings since these responses were normal in muscle disease control patients. An altered metabolic state also can cause diminished ventilatory response, but overall oxygen consumption data in the ragged-red fiber patients were normal. The decreased ventilatory responses may be clinically significant because two of the ragged-red fiber patients had episodes suspicious of hypoventilation with poor response to hypoxia.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalNeurology
Volume26
Issue number2
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

Neuromuscular Diseases
Slow-Twitch Muscle Fibers
Hypoventilation
Ophthalmoplegia
Respiratory Muscles
Hypercapnia
Muscle Weakness
Oxygen Consumption
Biopsy
Muscles
Hypoxia

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Carroll, J. E., Zwillich, C., Weil, J. V., & Brooke, M. H. (1976). Depressed ventilatory response in oculocraniosomatic neuromuscular disease. Neurology, 26(2), 140-146.

Depressed ventilatory response in oculocraniosomatic neuromuscular disease. / Carroll, James Edwin; Zwillich, Clifford; Weil, John V.; Brooke, Michael H.

In: Neurology, Vol. 26, No. 2, 01.01.1976, p. 140-146.

Research output: Contribution to journalArticle

Carroll, JE, Zwillich, C, Weil, JV & Brooke, MH 1976, 'Depressed ventilatory response in oculocraniosomatic neuromuscular disease', Neurology, vol. 26, no. 2, pp. 140-146.
Carroll JE, Zwillich C, Weil JV, Brooke MH. Depressed ventilatory response in oculocraniosomatic neuromuscular disease. Neurology. 1976 Jan 1;26(2):140-146.
Carroll, James Edwin ; Zwillich, Clifford ; Weil, John V. ; Brooke, Michael H. / Depressed ventilatory response in oculocraniosomatic neuromuscular disease. In: Neurology. 1976 ; Vol. 26, No. 2. pp. 140-146.
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