Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

A. S. Arbab, T. Ichikawa, T. Araki, K. Toyama, A. Nambu, S. Ohsawa, H. Kumagai, Y. Aikawa

Research output: Contribution to journalArticle

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Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1- weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density-weighted-FSE, and in- phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalAbdominal Imaging
Issue number2
StatePublished - Mar 1 2000



  • CTAP
  • HCC
  • MRI
  • Metastasis
  • SHU-555-A
  • SPIO

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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