Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

Ali Syed Arbab, T. Ichikawa, T. Araki, K. Toyama, A. Nambu, S. Ohsawa, H. Kumagai, Y. Aikawa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1- weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density-weighted-FSE, and in- phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalAbdominal Imaging
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Fingerprint

Echo-Planar Imaging
Hepatocellular Carcinoma
Neoplasm Metastasis
Noise
Magnetic Resonance Spectroscopy
Injections
Signal-To-Noise Ratio
Protons
Neoplasms
Liver
ferric oxide

Keywords

  • CTAP
  • HCC
  • MRI
  • Metastasis
  • SHU-555-A
  • SPIO

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A). / Arbab, Ali Syed; Ichikawa, T.; Araki, T.; Toyama, K.; Nambu, A.; Ohsawa, S.; Kumagai, H.; Aikawa, Y.

In: Abdominal Imaging, Vol. 25, No. 2, 01.03.2000, p. 151-158.

Research output: Contribution to journalArticle

Arbab, Ali Syed ; Ichikawa, T. ; Araki, T. ; Toyama, K. ; Nambu, A. ; Ohsawa, S. ; Kumagai, H. ; Aikawa, Y. / Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A). In: Abdominal Imaging. 2000 ; Vol. 25, No. 2. pp. 151-158.
@article{b836a80a4abc4a9ba9534b4f6b84c304,
title = "Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)",
abstract = "Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1- weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density-weighted-FSE, and in- phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.",
keywords = "CTAP, HCC, MRI, Metastasis, SHU-555-A, SPIO",
author = "Arbab, {Ali Syed} and T. Ichikawa and T. Araki and K. Toyama and A. Nambu and S. Ohsawa and H. Kumagai and Y. Aikawa",
year = "2000",
month = "3",
day = "1",
doi = "10.1007/s002619910035",
language = "English (US)",
volume = "25",
pages = "151--158",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

AU - Arbab, Ali Syed

AU - Ichikawa, T.

AU - Araki, T.

AU - Toyama, K.

AU - Nambu, A.

AU - Ohsawa, S.

AU - Kumagai, H.

AU - Aikawa, Y.

PY - 2000/3/1

Y1 - 2000/3/1

N2 - Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1- weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density-weighted-FSE, and in- phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.

AB - Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1- weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density-weighted-FSE, and in- phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.

KW - CTAP

KW - HCC

KW - MRI

KW - Metastasis

KW - SHU-555-A

KW - SPIO

UR - http://www.scopus.com/inward/record.url?scp=0034107801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034107801&partnerID=8YFLogxK

U2 - 10.1007/s002619910035

DO - 10.1007/s002619910035

M3 - Article

VL - 25

SP - 151

EP - 158

JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

IS - 2

ER -