Developing a novel test to detect cancer genes from microarray data

Shreya Mathur, Sunil Mathur

Research output: Contribution to journalArticle

Abstract

DNA microarray technology can simultaneously screen thousands of gene expression profiles, transforming how genetics is applied in medicine. However, the lack of normality in microarray data renders common statistical methods ineffective. We propose a novel statistical method which does not require stringent assumptions but is still more powerful than some of its competitors. Using both simulation studies and clinical data, we show that our novel method outperforms previous methods. The limiting distribution for the proposed test is obtained for under null and alternative hypotheses. The proposed test will help make cancer treatment and gene therapy more successful, and it may facilitate research regarding cancer vaccinations. The proposed test may also help in the development of a prediction model in genetic profiling studies built on a subset of differentially expressed genes and the clinical data to assess the accuracy of the clinical prediction.

Original languageEnglish (US)
Pages (from-to)628-646
Number of pages19
JournalInternational Journal of Bioinformatics Research and Applications
Volume10
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Neoplasm Genes
Microarrays
Statistical methods
Genes
Gene therapy
Oncology
Gene expression
Medicine
DNA
Genetic Models
Oligonucleotide Array Sequence Analysis
Transcriptome
Genetic Therapy
Vaccination
Technology
Research
Neoplasms
Genetics
Therapeutics

Keywords

  • Data
  • Differentially expressed genes
  • Location
  • Power
  • Test
  • Type I error

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Clinical Biochemistry
  • Health Information Management

Cite this

Developing a novel test to detect cancer genes from microarray data. / Mathur, Shreya; Mathur, Sunil.

In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 01.01.2014, p. 628-646.

Research output: Contribution to journalArticle

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