Development and Validation of a Prognostic Nomogram to Predict Cancer-Specific Survival in Adult Patients With Pineoblastoma

Yajun Jing, Wenshuai Deng, Huawei Zhang, Yunxia Jiang, Zuoxiang Dong, Fan Fan, Peng Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Pineoblastoma (PB) is a rare neoplasm of the central nervous system. This analysis aimed to identify factors and establish a predictive model for the prognosis of adult patients with PB. Data for 213 adult patients with PB (Surveillance, Epidemiology, and End Results database) were randomly divided into primary and validation cohorts. A predictive model was established and optimized based on the Akaike Information Criterion and visualized by a nomogram. Its predictive performance (concordance index and receiver operating characteristic curve) and clinical utility (decision curve analyses) were evaluated. We internally and externally validated the model using calibration curves. Multivariate Cox regression analysis identified age, year of diagnosis, therapy, tumor size, and tumor extension as independent predictors of PB. The model exhibited great discriminative ability (concordance index of the nomogram: 0.802; 95% confidence interval: 0.78–0.83; area under the receiver operating characteristic curve: ranging from 0.7 to 0.8). Calibration plots (probability of survival) showed good consistency between the actual observation and the nomogram prediction in both cohorts, and the decision curve analyses demonstrated great clinical utility of the nomogram. The nomogram is a useful and practical tool for evaluating prognosis and determining appropriate therapy strategies.

Original languageEnglish (US)
Article number1021
JournalFrontiers in Oncology
Volume10
DOIs
StatePublished - Jul 24 2020
Externally publishedYes

Keywords

  • C-index
  • nomogram
  • pineoblastoma
  • prognosis
  • risk factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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