Development of Retinal Amacrine Cells and Their Dendritic Stratification

Revathi Balasubramanian, Lin Gan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The mammalian retina contains multiple neurons, each of which contributes differentially to visual processing. Of these retinal neurons, amacrine cells have recently come to prime light since they facilitate majority of visual processing that takes place in the retina. Amacrine cells are also the most diverse group of neurons in the retina, classified majorly based on the neurotransmitter type they express and morphology of their dendritic arbors. Currently, little is known about the molecular basis contributing to this diversity during development. Amacrine cells also contribute to most of the synapses in the inner plexiform layer and mediate visual information input from bipolar cells onto retinal ganglion cells. In this review, we will describe the current understanding of amacrine cell and cell subtype development. Furthermore, we will address the molecular basis of retinal lamination at the inner plexiform layer. Overall, our review will provide a developmental perspective of amacrine cell subtype classification and their dendritic stratification.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalCurrent Ophthalmology Reports
Volume2
Issue number3
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Keywords

  • Amacrine cells
  • Dendritic stratification
  • Retina
  • Retinogenesis
  • Transcription factors

ASJC Scopus subject areas

  • Ophthalmology

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