Abstract
Summary. Helical strips of saphenous veins from diabetic (n=8) and non‐diabetic (n= 18) humans were studied in vivo for their responsiveness to several vasoactive agents. Following application of passive force (˜20·0 mN), venous strips from non‐diabetic humans often developed spontaneous phasic contractile activity (12 out of 18 patients; 2–5 contractions/min). These intrinsic changes in force were seen in venous strips from only one diabetic patient. The phasic contractions were not altered by treatment with phentolamine, whereas the calcium channel blocker, D‐600, and calcium‐free solution (1·0 mM EGTA) inhibited the phasic contractions. Saphenous veins from diabetic patients developed less maximal, active tension in response to norepinephrine than those from non‐diabetic patients. Contractile responses to serotonin, angiotensin II, and elevated potassium concentration in saphenous veins from diabetic patients were not different from those in veins from non‐diabetic patients. These observations demonstrate attenuated development of active tension in response to alpha‐adrenergic receptor activation and reduced spontaneous contractile activity in venous smooth muscle from diabetic patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 509-517 |
| Number of pages | 9 |
| Journal | Clinical Physiology |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1984 |
Fingerprint
ASJC Scopus subject areas
- Physiology
Cite this
Diabetes and reactivity of isolated human saphenous vein. / Cardwell, Robert J.; Webb, R. Clinton.
In: Clinical Physiology, Vol. 4, No. 6, 12.1984, p. 509-517.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diabetes and reactivity of isolated human saphenous vein
AU - Cardwell, Robert J.
AU - Webb, R. Clinton
PY - 1984/12
Y1 - 1984/12
N2 - Summary. Helical strips of saphenous veins from diabetic (n=8) and non‐diabetic (n= 18) humans were studied in vivo for their responsiveness to several vasoactive agents. Following application of passive force (˜20·0 mN), venous strips from non‐diabetic humans often developed spontaneous phasic contractile activity (12 out of 18 patients; 2–5 contractions/min). These intrinsic changes in force were seen in venous strips from only one diabetic patient. The phasic contractions were not altered by treatment with phentolamine, whereas the calcium channel blocker, D‐600, and calcium‐free solution (1·0 mM EGTA) inhibited the phasic contractions. Saphenous veins from diabetic patients developed less maximal, active tension in response to norepinephrine than those from non‐diabetic patients. Contractile responses to serotonin, angiotensin II, and elevated potassium concentration in saphenous veins from diabetic patients were not different from those in veins from non‐diabetic patients. These observations demonstrate attenuated development of active tension in response to alpha‐adrenergic receptor activation and reduced spontaneous contractile activity in venous smooth muscle from diabetic patients.
AB - Summary. Helical strips of saphenous veins from diabetic (n=8) and non‐diabetic (n= 18) humans were studied in vivo for their responsiveness to several vasoactive agents. Following application of passive force (˜20·0 mN), venous strips from non‐diabetic humans often developed spontaneous phasic contractile activity (12 out of 18 patients; 2–5 contractions/min). These intrinsic changes in force were seen in venous strips from only one diabetic patient. The phasic contractions were not altered by treatment with phentolamine, whereas the calcium channel blocker, D‐600, and calcium‐free solution (1·0 mM EGTA) inhibited the phasic contractions. Saphenous veins from diabetic patients developed less maximal, active tension in response to norepinephrine than those from non‐diabetic patients. Contractile responses to serotonin, angiotensin II, and elevated potassium concentration in saphenous veins from diabetic patients were not different from those in veins from non‐diabetic patients. These observations demonstrate attenuated development of active tension in response to alpha‐adrenergic receptor activation and reduced spontaneous contractile activity in venous smooth muscle from diabetic patients.
UR - http://www.scopus.com/inward/record.url?scp=0021680931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021680931&partnerID=8YFLogxK
U2 - 10.1111/j.1475-097X.1984.tb00136.x
DO - 10.1111/j.1475-097X.1984.tb00136.x
M3 - Article
C2 - 6097393
AN - SCOPUS:0021680931
VL - 4
SP - 509
EP - 517
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
SN - 1475-0961
IS - 6
ER -