Diagnosis and treatment of infections caused by rapidly growing mycobacteria

Rhonda E. Colombo, Kenneth N. Olivier

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Rapidly growing mycobacteria (RGM) are ubiquitous environmental organisms capable of causing a wide variety of infections in humans. The prevalence of RGM infections appears to be increasing, although exact incidence rates are unknown. Although some risk factors for pulmonary RGM infection have been determined, the specific host factors predisposing to disease in the majority of cases are not clear. Significant advances in molecular methods of mycobacterial identification have led to isolation of more varieties, changes in taxonomy, and more rapid and accurate diagnosis of RGM from clinical isolates. Despite significant advances in the field, diagnosing and treating RGM pulmonary infections remain complicated. Current guidelines are based on the most commonly encountered NTM. Their applicability to less frequent RGM isolates has not been definitively established. Treatment often requires multiple antimicrobial agents for prolonged periods of time, with varying degrees of success and significant associated morbidity.

Original languageEnglish (US)
Pages (from-to)577-588
Number of pages12
JournalSeminars in Respiratory and Critical Care Medicine
Volume29
Issue number5
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

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Keywords

  • Diagnosis
  • Nontuberculous mycobacteria (NTM)
  • Rapidly growing mycobacteria (RGM)
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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