Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome

Mark O. Goodarzi, Ricardo Azziz

Research output: Contribution to journalReview article

132 Scopus citations

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, and its definition remains fluid and controversial. PCOS is characterized by clinical and/or biochemical hyperandrogenism, and is frequently accompanied by ovulatory dysfunction and polycystic ovaries. PCOS is a diagnosis of exclusion, with other androgen excess and related disorders to be excluded. The prevalence of PCOS is 6.5-8.0% of unselected women of reproductive age, using the NIH 1990 criteria. Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive.

Original languageEnglish (US)
Pages (from-to)193-205
Number of pages13
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume20
Issue number2
DOIs
StatePublished - Jun 1 2006

Keywords

  • complex disorders
  • epidemiology
  • phenotyping
  • polycystic ovary syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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