Dietary Protein: Mechanisms Influencing Hypertension and Renal Disease

John Henry Dasinger, Daniel J. Fehrenbach, Justine M. Abais-Battad

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Purpose of Review: This review will provide an in-depth coverage of the epidemiological and pre-clinical literature surrounding the role of dietary protein in hypertension, with a special emphasis on the history of our work on the Dahl salt-sensitive rat. Recent Findings: Our studies have dedicated much effort into understanding the relationship between dietary protein and its effect on the development of salt-sensitive hypertension and renal injury. Our evidence over the last 15 years have demonstrated that both the source and amount of dietary protein can influence the severity of disease, where we have determined mechanisms related to immunity, the maternal environment during pregnancy, and more recently the gut microbiota, which significantly contribute to these diet-induced effects. Summary: Deeper understanding of these dietary protein-related mechanisms may provide insight on the plausibility of dietary modifications as future therapeutic avenues for hypertension and renal disease.

Original languageEnglish (US)
Article number13
JournalCurrent Hypertension Reports
Volume22
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Dietary protein
  • Hypertension
  • Inflammation
  • Microbiome
  • Pregnancy
  • Salt sensitivity

ASJC Scopus subject areas

  • Internal Medicine

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