Differences in Cyclophosphamide-Induced Suppression of Cricket Predation in Selectively Bred Strains of Taste-Aversion Prone and Resistant Rats

Ralph L. Elkins, Robert J. Gerardot, Stephen H. Hobbs

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cyclophosphamide-induced conditioned suppression of cricket predation was observed in tasteaversion-prone (TAP) but not in taste-aversion-resistant (TAR) rates. These TAP and TAR strains had been selectively bred for efficient or inefficient acquisition of cyclophosphamide-induced saccharin taste aversions (TAs). Equivalent preconditioning cricket predation was practiced by nonfasted subjects of both strains. TAR rats that ate crickets before a cyclophosphamide injection were thereafter voracious predators as were saline-injected and pseudoconditioning controls of both strains. However, conditioned TAP rats subsequently displayed a marked suppression of cricket predation. Predation can provide a deprivation-free and species-natural consummatory response for studies of strain differences in TA conditionability of TAP and TAR rats. In addition, the present results indicate that TAP and TAR strain differences in TA conditionability are not restricted to the saccharin solution that was the conditioned stimulus basis of prior strain development.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalBehavioral Neuroscience
Volume103
Issue number1
DOIs
StatePublished - Feb 1 1989

Fingerprint

Gryllidae
Cyclophosphamide
Saccharin
Injections

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Differences in Cyclophosphamide-Induced Suppression of Cricket Predation in Selectively Bred Strains of Taste-Aversion Prone and Resistant Rats. / Elkins, Ralph L.; Gerardot, Robert J.; Hobbs, Stephen H.

In: Behavioral Neuroscience, Vol. 103, No. 1, 01.02.1989, p. 112-116.

Research output: Contribution to journalArticle

@article{734da65a777e42bcbcda5aba539ed01f,
title = "Differences in Cyclophosphamide-Induced Suppression of Cricket Predation in Selectively Bred Strains of Taste-Aversion Prone and Resistant Rats",
abstract = "Cyclophosphamide-induced conditioned suppression of cricket predation was observed in tasteaversion-prone (TAP) but not in taste-aversion-resistant (TAR) rates. These TAP and TAR strains had been selectively bred for efficient or inefficient acquisition of cyclophosphamide-induced saccharin taste aversions (TAs). Equivalent preconditioning cricket predation was practiced by nonfasted subjects of both strains. TAR rats that ate crickets before a cyclophosphamide injection were thereafter voracious predators as were saline-injected and pseudoconditioning controls of both strains. However, conditioned TAP rats subsequently displayed a marked suppression of cricket predation. Predation can provide a deprivation-free and species-natural consummatory response for studies of strain differences in TA conditionability of TAP and TAR rats. In addition, the present results indicate that TAP and TAR strain differences in TA conditionability are not restricted to the saccharin solution that was the conditioned stimulus basis of prior strain development.",
author = "Elkins, {Ralph L.} and Gerardot, {Robert J.} and Hobbs, {Stephen H.}",
year = "1989",
month = "2",
day = "1",
doi = "10.1037/0735-7044.103.1.112",
language = "English (US)",
volume = "103",
pages = "112--116",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "1",

}

TY - JOUR

T1 - Differences in Cyclophosphamide-Induced Suppression of Cricket Predation in Selectively Bred Strains of Taste-Aversion Prone and Resistant Rats

AU - Elkins, Ralph L.

AU - Gerardot, Robert J.

AU - Hobbs, Stephen H.

PY - 1989/2/1

Y1 - 1989/2/1

N2 - Cyclophosphamide-induced conditioned suppression of cricket predation was observed in tasteaversion-prone (TAP) but not in taste-aversion-resistant (TAR) rates. These TAP and TAR strains had been selectively bred for efficient or inefficient acquisition of cyclophosphamide-induced saccharin taste aversions (TAs). Equivalent preconditioning cricket predation was practiced by nonfasted subjects of both strains. TAR rats that ate crickets before a cyclophosphamide injection were thereafter voracious predators as were saline-injected and pseudoconditioning controls of both strains. However, conditioned TAP rats subsequently displayed a marked suppression of cricket predation. Predation can provide a deprivation-free and species-natural consummatory response for studies of strain differences in TA conditionability of TAP and TAR rats. In addition, the present results indicate that TAP and TAR strain differences in TA conditionability are not restricted to the saccharin solution that was the conditioned stimulus basis of prior strain development.

AB - Cyclophosphamide-induced conditioned suppression of cricket predation was observed in tasteaversion-prone (TAP) but not in taste-aversion-resistant (TAR) rates. These TAP and TAR strains had been selectively bred for efficient or inefficient acquisition of cyclophosphamide-induced saccharin taste aversions (TAs). Equivalent preconditioning cricket predation was practiced by nonfasted subjects of both strains. TAR rats that ate crickets before a cyclophosphamide injection were thereafter voracious predators as were saline-injected and pseudoconditioning controls of both strains. However, conditioned TAP rats subsequently displayed a marked suppression of cricket predation. Predation can provide a deprivation-free and species-natural consummatory response for studies of strain differences in TA conditionability of TAP and TAR rats. In addition, the present results indicate that TAP and TAR strain differences in TA conditionability are not restricted to the saccharin solution that was the conditioned stimulus basis of prior strain development.

UR - http://www.scopus.com/inward/record.url?scp=0024580130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024580130&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.103.1.112

DO - 10.1037/0735-7044.103.1.112

M3 - Article

C2 - 2923664

AN - SCOPUS:0024580130

VL - 103

SP - 112

EP - 116

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 1

ER -