Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD

Kathryn A. Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The stimulus properties of the serotonin precursor 1-5-hydroxytrptophan (5-HTP) and the hallucinogen d-lysergic acid diethylamide (LSD) were compared in a two-lever, water-reinforced drug discrimination task. 5-HTP (in combination with the peripheral decarboxylase inhibitor Ro 4-4602) elicited no more than 50% drug-lever responding in rats trained to discriminate LSD (0.08 mg/kg) from saline while LSD substituted completely in animals trained to discriminate 5-HTP (50 mg/kg) from saline. Combination tests indicated that, while the 5-HTP cue was unaffected by pretreatment with various serotonin antagonists, the substitution of LSD for 5-HTP was abolished by the putative serotonin-2 antagonist ketanserin. It was concluded that LSD mimics 5-HTP by stimulating a subset of serotonin receptors activated by 5-HTP which are sensitive to ketanserin (serotonin-2?).

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalEuropean Journal of Pharmacology
Volume108
Issue number2
DOIs
StatePublished - Jan 22 1985

Fingerprint

5-Hydroxytryptophan
Lysergic Acid Diethylamide
Ketanserin
Serotonin Antagonists
Serotonin
Benserazide
Hallucinogens
Carboxy-Lyases
Pharmaceutical Preparations
Cues
Water

Keywords

  • 1-5-Hydroxytryptophan
  • Drug discrimination
  • Serotonin (5-hydroxytryptamine)
  • d-Lysergic acid diethylamide (LSD)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Differentiation between the stimulus effects of 1-5-hydroxytryptophan and LSD. / Cunningham, Kathryn A.; Callahan, Patrick M.; Appel, James B.

In: European Journal of Pharmacology, Vol. 108, No. 2, 22.01.1985, p. 179-186.

Research output: Contribution to journalArticle

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