Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Granulomatous Inflammation Mimicking High-Grade Malignancy on FDG-PET/CT

Joyce Hsu, Leo Jia, Darko Pucar, Hadyn Williams, Jayanth Keshavamurthy

Research output: Contribution to journalArticle

Abstract

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare form of preinvasive lung lesion associated with indolent carcinoid tumor formation. This disease is characterized by multiple small pulmonary nodules with low SUVmax on F-FDG PET. Biopsy and immunohistochemical staining for neuroendocrine markers confirm diagnosis. There is no consensus for treatment, which typically involves surgical excision or management of symptoms with steroid-based therapies. We report an unusual case of DIPNECH colocalizing with necrotizing granulomatous inflammation mimicking high-grade aggressive malignancy on FDG-PET and a typical case of DIPNECH for comparison with low FDG avidity.

Original languageEnglish (US)
Pages (from-to)47-49
Number of pages3
JournalClinical Nuclear Medicine
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2017

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Neuroendocrine Cells
Hyperplasia
Inflammation
Lung
Neoplasms
Multiple Pulmonary Nodules
Carcinoid Tumor
Steroids
Staining and Labeling
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Granulomatous Inflammation Mimicking High-Grade Malignancy on FDG-PET/CT. / Hsu, Joyce; Jia, Leo; Pucar, Darko; Williams, Hadyn; Keshavamurthy, Jayanth.

In: Clinical Nuclear Medicine, Vol. 42, No. 1, 01.01.2017, p. 47-49.

Research output: Contribution to journalArticle

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