Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta

Malliga E. Ganapathy, Virendra B. Mahesh, Lawrence D Devoe, Frederick H. Leibach, Vadivel Ganapathy

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We studied the transport of glycylsarcosine by the brush-border membrane vesicles isolated from normal term human placentas. This dipeptide resisted hydrolysis by placental membrane vesicles and was transported intact into an osmotically responsive intravesicular space. The transport process was Na+-independent and probably occurred down a concentration gradient. Many peptides inhibited the transport of glycylsarcosine whereas amino acids had no effect. These results demonstrate, for the first time, the presence of a dipeptide transport system in the human placenta.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume153
Issue number1
DOIs
StatePublished - Sep 1 1985

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Dipeptides
Microvilli
Placenta
Membranes
Hydrolysis
Amino Acids
Peptides
glycylsarcosine

Keywords

  • Dipeptide transport
  • Na independence
  • brush-border vesicle
  • human placenta

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta. / Ganapathy, Malliga E.; Mahesh, Virendra B.; Devoe, Lawrence D; Leibach, Frederick H.; Ganapathy, Vadivel.

In: American Journal of Obstetrics and Gynecology, Vol. 153, No. 1, 01.09.1985, p. 83-86.

Research output: Contribution to journalArticle

Ganapathy, Malliga E. ; Mahesh, Virendra B. ; Devoe, Lawrence D ; Leibach, Frederick H. ; Ganapathy, Vadivel. / Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta. In: American Journal of Obstetrics and Gynecology. 1985 ; Vol. 153, No. 1. pp. 83-86.
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