Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle

J. Hurley Myers, Thomas E. Mecca, R. Clinton Webb

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Serotonin has several effects on vascular smooth muscle. In most vascular beds it causes vasoconstriction, but under the proper conditions it can cause vasodilatation. The constrictor response is a result of activation of specific receptors on the vascular smooth muscle, whereas the vasodilator response is mediated in part by the vascular endothelium. In addition to these direct effects on the vascular wall, serotonin can potentiate contractile responses to several other vasoactive agents (norepinephrine. angiotensin II, histamine, etc.). This indirect sensitizing action of the monoamine is probably mediated by activation of the S2 subclass of serotonergic receptors. These complex actions of serotonin on vascular smooth muscle may he altered in disease states such as hypertension.

Original languageEnglish (US)
Pages (from-to)S44-S48
JournalJournal of Cardiovascular Pharmacology
Volume7
StatePublished - Jan 1 1985

Fingerprint

Serotonin Receptor Agonists
Serotonin Antagonists
Vascular Smooth Muscle
Serotonin
Blood Vessels
Vascular Endothelium
Vasoconstriction
Vasodilator Agents
Vasodilation
Angiotensin II
Histamine
Norepinephrine
Hypertension

Keywords

  • Endothelium
  • Hypertension
  • Methysergide
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle. / Hurley Myers, J.; Mecca, Thomas E.; Clinton Webb, R.

In: Journal of Cardiovascular Pharmacology, Vol. 7, 01.01.1985, p. S44-S48.

Research output: Contribution to journalArticle

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