Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle

J. Hurley Myers, Thomas E. Mecca, R. Clinton Webb

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Serotonin has several effects on vascular smooth muscle. In most vascular beds it causes vasoconstriction, but under the proper conditions it can cause vasodilatation. The constrictor response is a result of activation of specific receptors on the vascular smooth muscle, whereas the vasodilator response is mediated in part by the vascular endothelium. In addition to these direct effects on the vascular wall, serotonin can potentiate contractile responses to several other vasoactive agents (norepinephrine. angiotensin II, histamine, etc.). This indirect sensitizing action of the monoamine is probably mediated by activation of the S2 subclass of serotonergic receptors. These complex actions of serotonin on vascular smooth muscle may he altered in disease states such as hypertension.

Original languageEnglish (US)
Pages (from-to)S44-S48
JournalJournal of Cardiovascular Pharmacology
Volume7
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Endothelium
  • Hypertension
  • Methysergide
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle'. Together they form a unique fingerprint.

  • Cite this