Discriminative stimulus properties of clonidine: Substitution by ergot derivatives

Kathryn A. Cunningham; Patrick M. Callahan; Nancy A. Craigmyle; James B. Appel

doi:10.1016/0014-2999(85)90299-7

Discriminative stimulus properties of clonidine: Substitution by ergot derivatives

Kathryn A. Cunningham, Patrick M. Callahan, Nancy A. Craigmyle, James B. Appel

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.

Original language	English (US)
Pages (from-to)	225-229
Number of pages	5
Journal	European Journal of Pharmacology
Volume	119
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(85)90299-7
State	Published - Dec 17 1985
Externally published	Yes

Keywords

Bromocriptine
Clonidine
Dopamine
Drug discrimination
Lergotrile
Lisuride
d-Lysergic acid diethylamide (LSD)
α-Adrenoceptors

ASJC Scopus subject areas

Pharmacology

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title = "Discriminative stimulus properties of clonidine: Substitution by ergot derivatives",

abstract = "Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.",

keywords = "Bromocriptine, Clonidine, Dopamine, Drug discrimination, Lergotrile, Lisuride, d-Lysergic acid diethylamide (LSD), α-Adrenoceptors",

author = "Cunningham, {Kathryn A.} and Callahan, {Patrick M.} and Craigmyle, {Nancy A.} and Appel, {James B.}",

note = "Funding Information: This research was supported by USPHS Research Grant 2 R01 DNA 02543 from the National Institute on Drug Abuse. We wish to thank the following companies for their generous gifts of drugs: Boehringer Ingelheim Ltd., Ridgefield, CT (clonidine); Janssen Pharmaceutica, Brunswick, NJ (ketanserin); Eli Lilly & Co., Indianapolis, IN (lergotrile); Sandoz Pharmaceuticals, Hannover, NJ (BC 105, bromocriptine); Schering AG, Berlin, FRG (lisuride). LSD was supplied by the National Institute on Drug Abuse. We also thank Gary L. Collins for drafting the figures.",

year = "1985",

month = dec,

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doi = "10.1016/0014-2999(85)90299-7",

language = "English (US)",

volume = "119",

pages = "225--229",

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AU - Cunningham, Kathryn A.

AU - Callahan, Patrick M.

AU - Craigmyle, Nancy A.

AU - Appel, James B.

N1 - Funding Information: This research was supported by USPHS Research Grant 2 R01 DNA 02543 from the National Institute on Drug Abuse. We wish to thank the following companies for their generous gifts of drugs: Boehringer Ingelheim Ltd., Ridgefield, CT (clonidine); Janssen Pharmaceutica, Brunswick, NJ (ketanserin); Eli Lilly & Co., Indianapolis, IN (lergotrile); Sandoz Pharmaceuticals, Hannover, NJ (BC 105, bromocriptine); Schering AG, Berlin, FRG (lisuride). LSD was supplied by the National Institute on Drug Abuse. We also thank Gary L. Collins for drafting the figures.

PY - 1985/12/17

Y1 - 1985/12/17

N2 - Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.

AB - Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.

KW - Bromocriptine

KW - Clonidine

KW - Dopamine

KW - Drug discrimination

KW - Lergotrile

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KW - d-Lysergic acid diethylamide (LSD)

KW - α-Adrenoceptors

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Discriminative stimulus properties of clonidine: Substitution by ergot derivatives

Abstract

Keywords

ASJC Scopus subject areas

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