Abstract
Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-229 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 119 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 17 1985 |
| Externally published | Yes |
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Keywords
- Bromocriptine
- Clonidine
- Dopamine
- Drug discrimination
- Lergotrile
- Lisuride
- d-Lysergic acid diethylamide (LSD)
- α-Adrenoceptors
ASJC Scopus subject areas
- Pharmacology
Cite this
Discriminative stimulus properties of clonidine : Substitution by ergot derivatives. / Cunningham, Kathryn A.; Callahan, Patrick Michael; Craigmyle, Nancy A.; Appel, James B.
In: European Journal of Pharmacology, Vol. 119, No. 3, 17.12.1985, p. 225-229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discriminative stimulus properties of clonidine
T2 - Substitution by ergot derivatives
AU - Cunningham, Kathryn A.
AU - Callahan, Patrick Michael
AU - Craigmyle, Nancy A.
AU - Appel, James B.
PY - 1985/12/17
Y1 - 1985/12/17
N2 - Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.
AB - Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.
KW - Bromocriptine
KW - Clonidine
KW - Dopamine
KW - Drug discrimination
KW - Lergotrile
KW - Lisuride
KW - d-Lysergic acid diethylamide (LSD)
KW - α-Adrenoceptors
UR - http://www.scopus.com/inward/record.url?scp=0022410517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022410517&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(85)90299-7
DO - 10.1016/0014-2999(85)90299-7
M3 - Article
VL - 119
SP - 225
EP - 229
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -