Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice

Pandelakis A. Koni, Rosalba Sacca, Pornsri Lawton, Jeffrey L. Browning, Nancy H. Ruddle, Richard A. Flavell

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Abstract

Lymphotoxin α (LTα)-deficient mice revealed critical roles for LTα in lymphoid organogenesis, but it is not clear whether LTα functions through an LTα homotrimer (LTα3 or LTα/β heterotrimers. We generated LTβ-deficient mice and found them to lack Peyer's patches, peripheral lymph nodes, splenic germinal centers, and follicular dendritic cells. Unlike LTα-deficient mice, LTβ-deficient mice had cervical and mesenteric lymph nodes. Furthermore, the mesenteric lymph nodes had germinal center-like regions, although these structures appeared to lack follicular dendritic cells. The absence of cervical and mesenteric lymph nodes in LTα-deficient mice, and yet their presence in LTβ-deficient mice and in mice deficient in tumor necrosis factor receptor types I and II, suggest that LTα3 may signal via an as yet unidentified receptor.

Original languageEnglish (US)
Pages (from-to)491-500
Number of pages10
JournalImmunity
Volume6
Issue number4
DOIs
StatePublished - Apr 1 1997

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Koni, P. A., Sacca, R., Lawton, P., Browning, J. L., Ruddle, N. H., & Flavell, R. A. (1997). Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity, 6(4), 491-500. https://doi.org/10.1016/S1074-7613(00)80292-7