Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice

Pandelakis A. Koni, Rosalba Sacca, Pornsri Lawton, Jeffrey L. Browning, Nancy H. Ruddle, Richard A. Flavell

Research output: Contribution to journalArticle

493 Citations (Scopus)

Abstract

Lymphotoxin α (LTα)-deficient mice revealed critical roles for LTα in lymphoid organogenesis, but it is not clear whether LTα functions through an LTα homotrimer (LTα3 or LTα/β heterotrimers. We generated LTβ-deficient mice and found them to lack Peyer's patches, peripheral lymph nodes, splenic germinal centers, and follicular dendritic cells. Unlike LTα-deficient mice, LTβ-deficient mice had cervical and mesenteric lymph nodes. Furthermore, the mesenteric lymph nodes had germinal center-like regions, although these structures appeared to lack follicular dendritic cells. The absence of cervical and mesenteric lymph nodes in LTα-deficient mice, and yet their presence in LTβ-deficient mice and in mice deficient in tumor necrosis factor receptor types I and II, suggest that LTα3 may signal via an as yet unidentified receptor.

Original languageEnglish (US)
Pages (from-to)491-500
Number of pages10
JournalImmunity
Volume6
Issue number4
DOIs
StatePublished - Apr 1 1997

Fingerprint

Lymphotoxin-alpha
Organogenesis
Lymph Nodes
Follicular Dendritic Cells
Germinal Center
Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Peyer's Patches

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Koni, P. A., Sacca, R., Lawton, P., Browning, J. L., Ruddle, N. H., & Flavell, R. A. (1997). Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity, 6(4), 491-500. https://doi.org/10.1016/S1074-7613(00)80292-7

Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. / Koni, Pandelakis A.; Sacca, Rosalba; Lawton, Pornsri; Browning, Jeffrey L.; Ruddle, Nancy H.; Flavell, Richard A.

In: Immunity, Vol. 6, No. 4, 01.04.1997, p. 491-500.

Research output: Contribution to journalArticle

Koni, PA, Sacca, R, Lawton, P, Browning, JL, Ruddle, NH & Flavell, RA 1997, 'Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice', Immunity, vol. 6, no. 4, pp. 491-500. https://doi.org/10.1016/S1074-7613(00)80292-7
Koni, Pandelakis A. ; Sacca, Rosalba ; Lawton, Pornsri ; Browning, Jeffrey L. ; Ruddle, Nancy H. ; Flavell, Richard A. / Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. In: Immunity. 1997 ; Vol. 6, No. 4. pp. 491-500.
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