Distribution of 14C-formaldehyde after pulpotomy with formocresol.

D. R. Myers, H. K. Shoaf, T. R. Dirksen, D. H. Pashley, G. M. Whitford, K. E. Reynolds

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95 Scopus citations


Pulpotomies were performed on rhesus monkeys with use of formocresol to determine if there was uptake of 14C-formaldehyde into the systemic circulation after formocresol pulpotomies. Five-minute exposure of pulpal tissue to the 14C-formocresol resulted in the systemic absorption of approximately 1% of the dose. Two hours of exposure of pulp tissue to the 14C-formocresol did not increase the systemic absorption. Multiple sequential pulpotomies resulted in proportionately higher systemic absorption of 14C-formaldehyde. Application of 131I to pulpotomy sites indicated that formocresol compromises the microcirculation of the dental pulp. Autoradiography disclosed extensive concentrations of 14C-formaldehyde in the pulp, dentin, periodontal ligament, and bone.

Original languageEnglish (US)
Pages (from-to)805-813
Number of pages9
JournalJournal of the American Dental Association (1939)
Issue number5
StatePublished - May 1978
Externally publishedYes

ASJC Scopus subject areas

  • Dentistry(all)


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