DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?

H. HACHAM, S. E. FREEMAN, R. W. GANGE, D. J. MAYTUM, John C. Sutherland, B. M. SUTHERLAND

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad‐band UV‐B (290–320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV‐B sensitivity (low minimal erythema dose) than in subjects of low UV‐B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34–36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275–365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalPhotochemistry and Photobiology
Volume53
Issue number4
DOIs
StatePublished - Jan 1 1991

Fingerprint

Pyrimidine Dimers
pyrimidines
Erythema
Ultraviolet Rays
ultraviolet radiation
Skin
induction
deoxyribonucleic acid
dimers
Radiation
Dimers
DNA
radiation
Wavelength
sensitivity
wavelengths
Ultraviolet radiation
narrowband
Photons
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

Cite this

DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)? / HACHAM, H.; FREEMAN, S. E.; GANGE, R. W.; MAYTUM, D. J.; Sutherland, John C.; SUTHERLAND, B. M.

In: Photochemistry and Photobiology, Vol. 53, No. 4, 01.01.1991, p. 559-563.

Research output: Contribution to journalArticle

HACHAM, H. ; FREEMAN, S. E. ; GANGE, R. W. ; MAYTUM, D. J. ; Sutherland, John C. ; SUTHERLAND, B. M. / DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?. In: Photochemistry and Photobiology. 1991 ; Vol. 53, No. 4. pp. 559-563.
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abstract = "Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad‐band UV‐B (290–320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV‐B sensitivity (low minimal erythema dose) than in subjects of low UV‐B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34–36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275–365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.",
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